Lopadine Nasal Spray 665 mcg/spray is an effective antiallergic nasal spray formulated for the relief of symptoms associated with allergic rhinitis, including nasal congestion, sneezing, itching, and rhinorrhea. The active ingredient, Olopatadine Hydrochloride, is a second-generation selective histamine H1 receptor antagonist with proven efficacy in managing seasonal and perennial allergic rhinitis.

Lopadine works locally in the nasal mucosa, rapidly alleviating allergy symptoms while minimizing systemic exposure and side effects. Its fast onset of action and once or twice daily dosing make it convenient for both adults and adolescents.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antihistamines

• Nasal decongestants

• Antiallergic drugs

Pharmacology

Olopatadine Hydrochloride, the active ingredient in Lopadine Nasal Spray, is a selective H1-receptor antagonist that prevents histamine from binding to its receptor on target cells in the nasal mucosa. By blocking histamine activity, Lopadine reduces:

• Sneezing

• Nasal itching

• Runny nose

• Nasal congestion

In addition to its antihistaminic activity, Olopatadine also stabilizes mast cells, inhibiting the release of inflammatory mediators like leukotrienes and prostaglandins. This dual action provides both symptomatic relief and anti-inflammatory benefits in allergic conditions.

The systemic absorption of Olopatadine from nasal spray is minimal, reducing the risk of sedation or other systemic side effects commonly associated with first-generation antihistamines.

Indications

Lopadine Nasal Spray is indicated for:

• Seasonal allergic rhinitis (hay fever)

• Perennial allergic rhinitis

• Relief of nasal symptoms including:

  • Sneezing

  • Nasal itching

  • Runny nose (rhinorrhea)

  • Nasal congestion

Dosage and Administration

• Adults and children (12 years and older):

  • 1 spray per nostril twice daily

• Adolescents:

  • Same dosing as adults

• Administration:

  • Shake well before use

  • Prime the pump if using for the first time

  • Insert the nozzle into the nostril and spray while gently inhaling

  • Avoid blowing the nose immediately after administration

• Duration of treatment:

  • Continue as prescribed by the physician. Symptoms usually improve within minutes to hours of first administration.

Interactions

• No significant drug interactions have been reported due to minimal systemic absorption

• Caution with other H1-antihistamines to avoid additive effects

Contraindications

• Known hypersensitivity to Olopatadine Hydrochloride or any excipients in the nasal spray

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Lopadine Nasal Spray is generally well tolerated. Side effects, if they occur, are mild and transient:

• Nasal irritation or burning sensation

• Sneezing immediately after administration

• Bitter taste in the mouth

• Headache (rare)

Pregnancy & Lactation

• Limited data are available on the use of Olopatadine Nasal Spray in pregnant women

• Should be used only if clearly needed, after evaluating the risk-benefit ratio

• Excretion in human milk is unknown; use with caution while breastfeeding

Precautions & Warnings

• Avoid spraying in eyes or mouth

• Do not exceed the recommended dose

• Discontinue if allergic reactions or severe irritation occur

• Patients with severe renal or hepatic impairment should use cautiously

Storage Conditions

• Store in a cool, dry place below 25°C

• Protect from direct sunlight and keep out of reach of children

• Do not freeze the spray

Mode of Action

Lopadine Nasal Spray blocks histamine H1 receptors locally in the nasal mucosa, preventing histamine-induced allergy symptoms. Additionally, its mast cell-stabilizing effect reduces the release of other inflammatory mediators, helping to alleviate both acute and chronic allergic nasal symptoms.

Drug Classes

• H1-Antihistamines

• Nasal antiallergic agents.