Losart 100 mg Tablet contains Losartan Potassium, an Angiotensin II Receptor Blocker (ARB) used primarily for the treatment of hypertension and renal protection in patients with type-2 diabetes and proteinuria. By blocking the effects of angiotensin II, Losart helps relax blood vessels, lower blood pressure, and reduce strain on the heart and kidneys. It may be used alone or in combination with other antihypertensive agents such as thiazide diuretics.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Hypertension:
Losart 100 mg is indicated for the treatment of high blood pressure. It may be used as monotherapy or in combination with other antihypertensive medications (e.g., thiazide diuretics).

Renal Protection in Type-2 Diabetic Patients with Proteinuria:
In hypertensive patients with type-2 diabetes and proteinuria (urine albumin to creatinine ratio >300 mg/g), Losart helps delay the progression of renal disease and reduce the risk of worsening kidney function.

Therapeutic Class

Angiotensin-II Receptor Blocker (ARB)

Pharmacology

Losartan is the first orally active, non-peptide angiotensin II receptor blocker. It selectively binds to the AT1 receptor, found in tissues such as the heart, kidneys, adrenal glands, and vascular smooth muscle.

By blocking angiotensin II from binding to AT1 receptors, Losart:

• Prevents vasoconstriction

• Reduces aldosterone secretion

• Promotes vasodilation

• Lowers blood pressure

• Decreases sodium and water retention

This mechanism contributes to effective blood pressure control and renal protection in diabetic patients.

Dosage & Administration

General Adult Dose:

• Usual starting and maintenance dose: 50 mg once daily

• If blood pressure is not adequately controlled, dose may be increased up to 100 mg daily (once or divided into two doses).

Volume-depleted patients (e.g., on high-dose diuretics):

• Start with 25 mg once daily

Dose Range:

• Total daily dose: 25–100 mg

Losart may be taken with or without food.

Drug Interactions

• Rifampicin, Fluconazole: May decrease levels of active metabolite

• Hydrochlorothiazide: May enhance antihypertensive effect

• Potassium-sparing diuretics (spironolactone, triamterene, amiloride), potassium supplements: Risk of hyperkalemia

• NSAIDs (e.g., indomethacin): May reduce antihypertensive effect

• Combined use with ACE inhibitors, ARBs, NSAIDs, and diuretics increases risk of renal impairment

• Avoid combination with Aliskiren in diabetic patients

Contraindications

• Hypersensitivity to Losartan or any component

• Pregnancy

• Concomitant use with Aliskiren in patients with diabetes

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Losart 100 mg is generally well tolerated. Common side effects include:

• Dizziness

• Diarrhea

• Nasal congestion

• Cough

• Upper respiratory infection

Other possible effects:

• Fatigue

• Edema

• Chest pain

• Nausea

• Headache

• Pharyngitis

Precautions & Warnings

• Risk of fetal toxicity when used during the second and third trimesters

• May cause symptomatic hypotension in volume-depleted patients

• Higher plasma levels observed in patients with hepatic impairment

• Monitor renal function in patients with kidney disease

Pregnancy & Lactation

Pregnancy Category D.
Use during the second and third trimesters increases the risk of fetal injury or death.

It is unknown whether Losartan is excreted in human milk. A decision should be made whether to discontinue breastfeeding or discontinue the drug, considering its importance to the mother.

Mode of Action

Losart 100 mg works by selectively blocking angiotensin II at the AT1 receptor. This prevents vasoconstriction and aldosterone release, resulting in lowered blood pressure, reduced fluid retention, and improved renal protection.

Storage Conditions

Store in a dry place, protected from heat and light. Keep out of reach of children.