Losart 50 mg Tablet contains Losartan Potassium, an orally active Angiotensin II Receptor Blocker (ARB) used for the management of hypertension and renal protection in patients with type-2 diabetes and proteinuria. It works by selectively blocking the binding of angiotensin II to the AT1 receptor, thereby reducing blood pressure and protecting vital organs such as the heart and kidneys.

Losartan is the first non-peptide, orally active angiotensin II receptor antagonist. By inhibiting angiotensin II–mediated vasoconstriction and aldosterone secretion, Losart 50 mg effectively lowers blood pressure and reduces cardiovascular and renal complications associated with long-standing hypertension.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Angiotensin II Receptor Blocker (ARB)

• Antihypertensive Agent

Indications

Losart 50 mg is indicated for:

• Hypertension:
  Used alone or in combination with other antihypertensive agents (e.g., thiazide diuretics) to control high blood pressure.

• Renal Protection in Type-2 Diabetes with Proteinuria:
  Recommended in hypertensive patients with type-2 diabetes and proteinuria (urine albumin-to-creatinine ratio >300 mg/g) to delay progression of diabetic nephropathy and reduce the risk of worsening renal disease.

Pharmacology & Mode of Action

Losartan selectively blocks the AT1 receptor located in vascular smooth muscle, heart, kidneys, and adrenal glands. By inhibiting angiotensin II action, it:

• Prevents vasoconstriction

• Reduces aldosterone secretion

• Decreases sodium and water retention

• Lowers systemic vascular resistance

• Protects kidney function in diabetic patients

Unlike ACE inhibitors, Losartan does not inhibit bradykinin breakdown, which reduces the risk of persistent cough.

Dosage & Administration

• Initial and Maintenance Dose: 50 mg once daily for most patients.

• If blood pressure control is inadequate, dose may be increased up to 100 mg daily (either once daily or divided into two doses).

• In patients with intravascular volume depletion (e.g., those on high-dose diuretics), a lower starting dose of 25 mg once daily is recommended.

Total daily dose range: 25 mg to 100 mg.

Losart may be taken with or without food.

Drug Interactions

• Rifampicin and Fluconazole: May decrease active metabolite levels.

• Potassium-sparing diuretics (e.g., spironolactone), potassium supplements, or potassium-containing salt substitutes: Increase risk of hyperkalemia.

• NSAIDs (e.g., indomethacin): May reduce antihypertensive effect and increase risk of renal impairment.

• ACE inhibitors or Aliskiren (in diabetic patients): Increased risk of renal dysfunction and hyperkalemia.

Contraindications

• Hypersensitivity to Losartan or any component of the formulation

• Pregnancy

• Concomitant use with Aliskiren in patients with diabetes

Side Effects

Losart 50 mg is generally well tolerated. Common side effects include:

• Dizziness

• Diarrhea

• Nasal congestion

• Cough

• Upper respiratory tract infection

Less common effects:

• Fatigue

• Edema

• Chest pain

• Headache

• Nausea

• Pharyngitis

Precautions & Warnings

• Avoid use during pregnancy (especially second and third trimesters) due to risk of fetal injury or death.

• Monitor renal function in patients with renal impairment.

• Symptomatic hypotension may occur in volume-depleted patients.

• Patients with hepatic impairment may have increased plasma concentrations.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy & Lactation

• Pregnancy Category D: Contraindicated due to risk of fetal harm.

• Use during breastfeeding should be carefully evaluated; discontinue either the drug or nursing based on clinical necessity.

Storage Conditions

• Store in a dry place away from heat and light.

• Keep out of reach of children.

Losart 50 mg Tablet is an effective and well-established ARB for controlling hypertension and protecting kidney function in diabetic patients, helping reduce long-term cardiovascular and renal complications.