Metarin XR Tablet 1000 mg is an extended-release formulation of Metformin Hydrochloride, a first-line oral antidiabetic medication used in the management of type 2 diabetes mellitus. It is specially designed to provide gradual and sustained release of the active ingredient, ensuring long-lasting blood glucose control with improved tolerability.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Metformin Hydrochloride 1000 mg
• Dosage Form: Extended-release (XR) tablet

Indications

Metarin XR 1000 mg is indicated for:

• Management of type 2 diabetes mellitus when diet and exercise alone are insufficient
• Use as monotherapy or in combination with other oral antidiabetic agents or insulin
• Reduction of fasting and postprandial blood glucose levels
• Off-label use in conditions such as polycystic ovary syndrome (PCOS)

Mechanism of Action

Metformin Hydrochloride works by improving glycemic control through multiple mechanisms:

• Reduces hepatic glucose production (gluconeogenesis)
• Enhances peripheral glucose uptake and insulin sensitivity
• Decreases intestinal glucose absorption
• Does not stimulate insulin secretion, minimizing the risk of hypoglycemia

Dosage and Administration

• Initial dose: Typically 500 mg to 1000 mg once daily with the evening meal
• Dose may be increased gradually based on glycemic response
• Maximum recommended dose: 2000 mg per day
• Tablets must be swallowed whole; do not crush, chew, or split

Dosage adjustments are necessary for elderly patients and those with impaired kidney function.

Benefits of Extended-Release Formulation

• Provides steady and prolonged glucose control
• Reduces gastrointestinal side effects such as diarrhea and nausea
• Enhances patient adherence with once-daily dosing
• Helps maintain consistent plasma drug levels

Side Effects

Common side effects:

• Nausea and vomiting
• Diarrhea
• Abdominal discomfort
• Metallic taste

Less common but serious:

• Lactic acidosis (rare but potentially life-threatening)
• Vitamin B12 deficiency with long-term therapy

Precautions and Warnings

• Contraindicated in patients with severe renal impairment
• Use with caution in elderly patients
• Avoid excessive alcohol intake due to increased risk of lactic acidosis
• Temporarily discontinue before major surgery or iodinated contrast imaging

Regular monitoring of kidney function is recommended during therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Iodinated contrast agents may increase risk of lactic acidosis
• Some medications (e.g., diuretics, corticosteroids) may affect blood glucose levels
• Alcohol may potentiate adverse effects

Storage Conditions

• Store in a cool, dry place below 25°C
• Protect from light and moisture
• Keep out of reach of children.