Metarin XR Tablet 500 mg contains Metformin Hydrochloride in an extended-release (XR) formulation, widely used for the management of type 2 diabetes mellitus. This medication belongs to the biguanide class of oral antidiabetic agents and is designed to provide prolonged glucose control with once-daily dosing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Metformin Hydrochloride 500 mg
• Dosage Form: Extended-release tablet

Indications

Metarin XR 500 mg is indicated for:

• Treatment of type 2 diabetes mellitus, especially in overweight patients when diet and exercise alone are insufficient
• Use as monotherapy or in combination with other oral antidiabetic drugs or insulin
• Prevention or delay of diabetes in high-risk individuals (prediabetes)
• Management of polycystic ovary syndrome (PCOS) (off-label use)

Mechanism of Action

Metformin works through multiple pathways to reduce blood glucose levels:

• Decreases hepatic glucose production (gluconeogenesis)
• Improves insulin sensitivity in muscle and adipose tissues
• Reduces intestinal absorption of glucose
• Does not stimulate insulin secretion, lowering the risk of hypoglycemia

Dosage and Administration

• Recommended starting dose: 500 mg once daily with the evening meal
• Dose may be increased gradually (usually weekly) based on patient response
• Maximum dose: Up to 2000 mg per day
• Tablets should be swallowed whole; do not crush or chew

Dose adjustment may be required in elderly patients or those with renal impairment.

Benefits of Extended-Release Formulation

• Provides sustained glucose control throughout the day
• Reduces gastrointestinal side effects compared to immediate-release forms
• Improves patient compliance due to once-daily dosing

Side Effects

Common side effects:

• Nausea, vomiting
• Diarrhea or abdominal discomfort
• Metallic taste
• Mild weight loss

Serious but rare:

• Lactic acidosis (a medical emergency)
• Vitamin B12 deficiency with long-term use

Precautions and Warnings

• Contraindicated in severe renal impairment (eGFR <30 mL/min)
• Use cautiously in elderly patients
• Avoid excessive alcohol consumption
• Temporary discontinuation may be required before contrast imaging procedures

Regular monitoring of kidney function and vitamin B12 levels is recommended.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Interaction with iodinated contrast media may increase risk of lactic acidosis
• Certain drugs (e.g., diuretics, cationic drugs) may alter metformin levels
• Alcohol increases the risk of serious side effects

Storage Conditions

• Store below 25°C
• Protect from moisture and heat
• Keep out of reach of children.