Vorifast Tablet 50 mg contains Voriconazole, a broad-spectrum triazole antifungal medicine used for the treatment of serious fungal infections. It is commonly prescribed for invasive aspergillosis, serious candidiasis, and other systemic fungal infections, particularly in immunocompromised patients such as those undergoing chemotherapy, organ transplantation, or suffering from severe immune suppression.

Voriconazole works by inhibiting the fungal enzyme lanosterol 14-α-demethylase, which is essential for the synthesis of ergosterol. Ergosterol is a key structural component of fungal cell membranes. By blocking its production, Voriconazole disrupts the integrity of the fungal cell membrane, leading to inhibition of fungal growth and eventual cell death.

Vorifast Tablet 50 mg is often used in combination therapy or as part of a step-down regimen following injectable treatment. It may also be used in dose-adjusted regimens where lower strengths are required for precise dosing based on body weight, age, liver function, or clinical response.

This medicine should only be used under strict medical supervision due to its potency, potential drug interactions, and need for careful monitoring. Regular assessment of liver function and clinical response is essential during treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Voriconazole BP 50 mg

Indications

Vorifast Tablet is indicated for:

• Invasive aspergillosis
• Serious Candida infections
• Esophageal candidiasis
• Scedosporium infections
• Fusarium infections
• Severe systemic fungal infections in immunocompromised patients

How It Works

Voriconazole inhibits lanosterol 14-α-demethylase, an enzyme required for ergosterol synthesis in fungal cell membranes. This leads to weakened cell membranes, inhibition of fungal growth, and eventual fungal cell death.

Dosage and Administration

The dosage should be strictly followed as prescribed by a registered physician.

• Administered orally as directed, usually twice daily after a loading dose (if prescribed)
• Dose may be adjusted based on weight, liver function, and therapeutic response
• Should be taken on an empty stomach or as advised by the physician
• Do not skip doses and complete the full course of therapy

Benefits of Vorifast Tablet

• Effective against a wide range of serious fungal infections
• Suitable for step-down therapy from injection to oral treatment
• Allows flexible dosing with multiple strengths
• Useful in long-term management of systemic fungal infections
• Strong and targeted antifungal action

Precautions

Use cautiously in:

• Patients with liver impairment
• Patients with heart rhythm disorders (QT prolongation)
• Kidney impairment
• Elderly or debilitated patients
• Pregnant or breastfeeding women unless clearly necessary

Regular monitoring of liver enzymes, vision changes, and drug interactions is required during therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Visual disturbances (blurred vision, altered color perception)
• Nausea and vomiting
• Headache
• Rash
• Abdominal pain
• Elevated liver enzymes
• Dizziness

Serious reactions such as liver toxicity, severe skin reactions, or cardiac rhythm disturbances require immediate medical attention.

Storage

• Store below 30°C
• Protect from light and moisture
• Keep in a dry place
• Keep out of reach of children.