Miraba Tablet 10 mg contains Mirogabalin Besylate, a selective α2δ ligand of voltage-gated calcium channels, designed for the management of chronic neuropathic pain. This higher-dose formulation is indicated for patients who require increased therapeutic effect for peripheral neuropathic pain, such as that associated with diabetic neuropathy or postherpetic neuralgia, offering significant improvement in pain control and quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antineuropathic Agent / Calcium Channel α2δ Ligand

Indications

Miraba Tablet 10 mg is indicated for:

• Peripheral neuropathic pain associated with diabetes (diabetic neuropathy)

• Postherpetic neuralgia following shingles infection

• Chronic neuropathic pain not adequately managed with lower doses or conventional analgesics

Pharmacology

Mirogabalin Besylate binds selectively to the α2δ subunit of voltage-gated calcium channels in the central nervous system. By inhibiting calcium influx in overactive neurons, it reduces the release of excitatory neurotransmitters involved in pain signaling. This mechanism results in:

• Decreased neuronal hyperexcitability

• Attenuation of spontaneous and evoked neuropathic pain

• Targeted action with reduced central nervous system adverse effects compared to traditional gabapentinoids

Dosage and Administration

• Recommended dose: 10 mg orally, once daily

• Dose may be adjusted based on patient response and tolerability

• Tablets should be swallowed whole with water, with or without food

• Dose adjustments may be necessary for patients with renal impairment

• Regular assessment of pain control and side effects is advised

Side Effects

Common side effects may include:

• Dizziness or drowsiness

• Headache

• Nausea or vomiting

• Peripheral edema

Less common but serious side effects:

• Confusion or mood changes

• Allergic reactions (rash, itching, swelling)

• Impaired coordination or balance

• Sedation affecting daily activities

Contraindications

• Hypersensitivity to Mirogabalin or any component of the formulation

• Severe renal impairment without dose adjustment

• Pregnancy and lactation unless prescribed by a healthcare provider

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

• Use caution in elderly patients or those prone to falls or sedation

• Avoid alcohol or concomitant CNS depressants while taking Miraba

• Not suitable for acute pain or sudden-onset pain episodes

• Monitor for central nervous system depression and signs of mood changes

Drug Interactions

• May potentiate sedative effects when used with alcohol, benzodiazepines, or other CNS depressants

• Dose adjustments may be required in patients receiving multiple medications affecting renal clearance or CNS function

Storage

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Keep out of reach of children

Mode of Action

Mirogabalin Besylate selectively targets the α2δ subunit of voltage-gated calcium channels in the CNS, reducing the release of excitatory neurotransmitters. This action attenuates peripheral neuropathic pain signals, providing effective relief from chronic nerve pain while minimizing systemic side effects.