Monocard-SR Capsule 50 mg contains Isosorbide Mononitrate in a sustained-release formulation, designed for the long-term prevention of angina pectoris (chest pain) associated with coronary artery disease. Unlike immediate-release nitrates, the sustained-release (SR) formulation provides a steady release of the active ingredient over an extended period, maintaining therapeutic blood levels for prolonged angina prophylaxis. Monocard-SR helps reduce the frequency and severity of angina attacks, improves exercise tolerance, and supports overall cardiovascular health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Isosorbide Mononitrate 50 mg per sustained-release capsule

Indications

Monocard-SR Capsule 50 mg is indicated for:

• Prophylaxis of angina pectoris in patients with coronary artery disease

• Long-term management of stable angina

• Reduction of frequency and intensity of chest pain episodes

• Supportive therapy in patients with compromised myocardial blood flow

This formulation is suitable for adult patients who require continuous angina management throughout the day, offering the convenience of less frequent dosing.

Mechanism of Action

Isosorbide Mononitrate is a nitrate that relaxes smooth muscles of blood vessels, leading to vasodilation. Its key mechanisms include:

• Peripheral vasodilation: Reduces venous return (preload) and decreases the workload on the heart

• Coronary artery dilation: Enhances blood flow to the myocardium, ensuring adequate oxygen delivery

• Reduction of cardiac oxygen demand: By decreasing both preload and afterload, the heart requires less oxygen, preventing ischemic episodes that trigger angina

The sustained-release design ensures continuous delivery of Isosorbide Mononitrate, maintaining a stable therapeutic effect throughout the day, minimizing fluctuations in blood levels that could lead to breakthrough angina attacks.

Dosage and Administration

• The typical starting dose is one 50 mg capsule once daily, preferably in the morning, or as prescribed by a physician.

• Depending on clinical response, the dose may be adjusted. Some patients may require dosing intervals of 12–24 hours.

• Capsules should be swallowed whole with water. Do not crush, chew, or split the capsule, as this may disrupt the sustained-release mechanism.

• Regular dosing is essential for optimal angina prevention.

Monocard-SR is not intended for the immediate relief of acute angina; fast-acting nitroglycerin should be available for sudden attacks if prescribed.

Benefits

• Provides long-lasting prevention of angina attacks

• Improves exercise tolerance and daily activity levels

• Reduces the frequency and severity of chest pain episodes

• Sustained-release formulation ensures continuous therapeutic effect

• Enhances quality of life for patients with coronary artery disease

Regular use under medical supervision allows patients to manage angina effectively and reduces limitations caused by recurrent chest pain.

Precautions

• Contraindicated in patients with severe hypotension, shock, or known hypersensitivity to nitrates.

• Use cautiously in patients with severe anemia, glaucoma, or increased intracranial pressure.

• Avoid co-administration with phosphodiesterase inhibitors (e.g., sildenafil) due to risk of severe hypotension.

• Pregnant and breastfeeding women should use only under medical guidance.

• Inform your physician about all medications being taken to prevent interactions.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Monocard-SR Capsule 50 mg is generally well tolerated. Common side effects may include:

• Headache (often mild to moderate)

• Dizziness or lightheadedness

• Flushing or warmth of the skin

• Nausea or gastrointestinal discomfort

• Rarely, hypotension or fainting

Most side effects are transient and tend to diminish with continued use.

Storage Instructions

• Store below 30°C in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.

Conclusion

Monocard-SR Capsule 50 mg (Isosorbide Mononitrate) is an effective sustained-release nitrate for the prevention of angina pectoris. By improving coronary blood flow and reducing cardiac workload, it helps prevent chest pain episodes, supports cardiovascular health, and enhances quality of life. With proper medical supervision, Monocard-SR offers long-lasting, convenient, and reliable prophylactic therapy for adults with coronary artery disease.