Nervalin CR Tablet 165 mg contains Pregabalin in a controlled-release (CR) formulation developed to deliver the medication gradually over an extended period. This once-daily dosage form helps maintain stable blood levels of pregabalin, ensuring continuous symptom control while improving patient convenience and adherence. Nervalin CR is widely used in the management of chronic neuropathic pain and as adjunctive therapy for specific neurological disorders.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Supplemental anti-epileptic medication

Indications

Nervalin CR Tablet 165 mg is indicated for the treatment of:

• Neuropathic pain associated with diabetic peripheral neuropathy (DPN)

• Post-herpetic neuralgia (nerve pain following shingles)

• Neuropathic pain associated with spinal cord injury

• Fibromyalgia

• Adjunctive therapy for partial-onset seizures

The controlled-release formulation is particularly suitable for patients who require sustained pain relief throughout the day with reduced dosing frequency.

Pharmacology

Pregabalin is a structural analogue of gamma-aminobutyric acid (GABA), although it does not act directly on GABA receptors. It binds selectively and with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces calcium influx into presynaptic neurons and decreases the release of excitatory neurotransmitters involved in pain transmission and seizure activity. Pregabalin is rapidly absorbed, has high oral bioavailability, and is eliminated primarily unchanged by the kidneys.

Dosage and Administration

Nervalin CR Tablet 165 mg is intended for once-daily oral administration, preferably taken after the evening meal.

• It is commonly used as a starting or step-up dose in patients being converted from immediate-release pregabalin capsules.

• Dosage should be individualized based on clinical response, tolerability, and renal function.

• The tablet should be swallowed whole and must not be crushed, split, or chewed to preserve the controlled-release properties.

Gradual dose titration is recommended to minimize adverse effects, and dose adjustment is required in patients with renal impairment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Nervalin CR Tablet 165 mg is contraindicated in patients with known hypersensitivity to pregabalin or to any component of the formulation.

Side Effects

Common adverse effects include dizziness, somnolence, dry mouth, blurred vision, peripheral edema, weight gain, and difficulty with concentration or attention. These effects are generally dose-dependent and often lessen with continued use.

Precautions and Warnings

Caution should be exercised in patients with renal insufficiency, heart failure, or those receiving other central nervous system depressants. Pregabalin may cause drowsiness or dizziness, which can impair the ability to drive or operate machinery. Abrupt discontinuation should be avoided; the dose should be tapered gradually to reduce the risk of withdrawal symptoms or increased seizure frequency.

Pregnancy and Lactation

Nervalin CR Tablet 165 mg should be used during pregnancy only when the expected benefit outweighs the potential risk to the fetus. Pregabalin is excreted in breast milk; therefore, caution is advised when used by breastfeeding mothers.

Storage Conditions

Store in a cool and dry place below 30°C, protected from light and moisture. Keep out of the reach of children.