Avloclav Tablet 250 mg+125 mg is a broad-spectrum antibiotic combining Amoxicillin 250 mg and Clavulanic Acid 125 mg. This formulation is effective against a wide range of bacterial infections, including those caused by beta-lactamase-producing bacteria that are resistant to amoxicillin alone. Amoxicillin works by inhibiting bacterial cell wall synthesis, while Clavulanic Acid protects amoxicillin from enzymatic degradation, enhancing its antibacterial activity. This lower-strength tablet is suitable for children and adults requiring adjusted dosing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Amoxicillin: 250 mg – penicillin-class antibiotic that inhibits bacterial cell wall synthesis
• Clavulanic Acid: 125 mg – beta-lactamase inhibitor that protects amoxicillin from enzymatic breakdown

Mechanism of Action

• Amoxicillin: Binds to bacterial penicillin-binding proteins (PBPs), preventing cell wall formation and leading to bacterial death
• Clavulanic Acid: Inhibits beta-lactamase enzymes, allowing amoxicillin to remain effective against resistant bacteria
• Provides enhanced antibacterial efficacy against Gram-positive and Gram-negative bacteria

Indications

Avloclav Tablet 250 mg+125 mg is indicated for:

• Respiratory tract infections: bronchitis, pneumonia, sinusitis
• Ear, nose, and throat infections: tonsillitis, pharyngitis, otitis media
• Urinary tract infections
• Skin and soft tissue infections: abscesses, cellulitis, wound infections
• Dental infections
• Mild to moderate infections caused by susceptible bacteria

Dosage and Administration

• Adults and children: 1 tablet every 12–24 hours, depending on infection severity and physician recommendation
• Swallow the tablet whole with a glass of water; can be taken with or without food
• Complete the full prescribed course, even if symptoms improve early
• Do not split, crush, or chew the tablet

Benefits

• Effective against beta-lactamase-producing resistant bacteria
• Treats a wide range of respiratory, urinary, skin, and dental infections
• Suitable for children and adults requiring lower doses
• Reduces risk of treatment failure due to bacterial resistance

Possible Side Effects

Common side effects:

• Nausea, vomiting, diarrhea
• Mild rash or itching
• Headache

Rare but serious side effects:

• Severe allergic reactions (anaphylaxis, swelling, difficulty breathing)
• Liver enzyme abnormalities or jaundice
• Clostridium difficile-associated diarrhea

Precautions and Warnings

• Contraindicated in patients with penicillin allergy
• Use cautiously in patients with renal impairment
• Monitor for allergic reactions or severe gastrointestinal symptoms
• Not effective for viral infections
• Inform your physician of all other medications being taken

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with oral anticoagulants, methotrexate, allopurinol, and other antibiotics
• May reduce effectiveness of oral contraceptives
• Dose adjustment may be required in renal impairment

Storage Instructions

• Store at 15–25°C in a cool, dry place, protected from light
• Keep the tablet in its original packaging until use
• Keep out of reach of children
• Do not use after the expiry date.