Novatron Injection 8 mg/4 ml contains Ondansetron, a selective serotonin 5-HT3 receptor antagonist widely used to prevent and control nausea and vomiting. It is particularly effective in patients undergoing chemotherapy, radiotherapy, or surgical procedures.

This injectable formulation is ideal for hospital and clinical settings where rapid action is required or when oral administration is not possible due to persistent vomiting or perioperative conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Fast-acting relief from nausea and vomiting

• Effective in chemotherapy-induced nausea and vomiting (CINV)

• Reduces post-operative nausea and vomiting (PONV)

• Suitable for IV or IM administration

• Well tolerated with a favorable safety profile

Indications

Novatron Injection 8 mg/4 ml is indicated for:

• Prevention and treatment of chemotherapy-induced nausea and vomiting

• Prevention and treatment of radiotherapy-induced nausea and vomiting

• Prevention and management of post-operative nausea and vomiting

• Severe nausea requiring injectable antiemetic therapy,

Dosage and Administration

• Administered by intravenous (slow IV injection or infusion) or intramuscular route.

• The usual adult dose is 8 mg prior to chemotherapy, radiotherapy, or anesthesia, as directed by a physician.

• Dosage may vary depending on age, body weight, and clinical condition.

• In patients with severe hepatic impairment, the total daily dose should not exceed recommended limits.

Administration must be performed by trained healthcare professionals under appropriate medical supervision.

Mechanism of Action

Ondansetron works by selectively blocking 5-HT3 receptors located in the gastrointestinal tract and the chemoreceptor trigger zone (CTZ) of the brain. During chemotherapy, radiotherapy, or surgical stress, serotonin is released in the gut, which stimulates the vomiting reflex. By inhibiting these receptors, ondansetron effectively prevents the initiation of nausea and vomiting.

Safety Information

Contraindications:

• Hypersensitivity to ondansetron or other 5-HT3 receptor antagonists

• Concomitant use with apomorphine

Warnings and precautions:

• May cause QT interval prolongation; use cautiously in patients with cardiac disorders

• Monitor in patients with electrolyte imbalance (e.g., hypokalemia, hypomagnesemia)

• Use cautiously in patients with hepatic impairment

Common side effects may include:

• Headache

• Constipation

• Dizziness

• Flushing

Serious adverse reactions are rare but may include allergic reactions and cardiac rhythm abnormalities.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store below 30°C, protected from light. Do not freeze. Keep out of reach of children.