Numira Tablet 5 mg contains Mirogabalin Besylate, a next-generation α2δ ligand developed for the effective management of neuropathic pain. Neuropathic pain arises from nerve injury or dysfunction and is often chronic, persistent, and difficult to treat. Numira Tablet 5 mg is formulated to provide sustained pain relief while maintaining a favorable safety and tolerability profile.

Mirogabalin is distinguished by its high binding affinity and prolonged action at the α2δ-1 subunit of voltage-gated calcium channels, which are critically involved in pain signaling pathways. This targeted mechanism allows Numira Tablet 5 mg to reduce pain intensity and improve daily functioning and quality of life in patients with neuropathic disorders.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন 

Indications

Numira Tablet 5 mg is indicated for the treatment of:

• Peripheral neuropathic pain

• Diabetic peripheral neuropathy

• Postherpetic neuralgia

• Other neuropathic pain conditions as diagnosed by a physician

Therapeutic Class

Neuropathic Pain Modulator / Anticonvulsant (α2δ Ligand)

Pharmacology / Mode of Action

Mirogabalin Besylate works by selectively binding to the α2δ-1 and α2δ-2 subunits of voltage-gated calcium channels located in the central nervous system. This binding inhibits calcium influx into presynaptic neurons, leading to reduced release of excitatory neurotransmitters such as glutamate, substance P, and norepinephrine.

By suppressing excessive neuronal firing and neurotransmitter release, Mirogabalin decreases neuronal hyperexcitability and interrupts pain transmission. Compared to other α2δ ligands, Mirogabalin shows more sustained receptor binding, which contributes to prolonged analgesic effects and improved tolerability with fewer central nervous system adverse effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন 

Dosage & Administration

The dosage of Numira Tablet 5 mg should be individualized according to patient response, severity of pain, and renal function.

• Administered orally with or without food

• Treatment is usually initiated at a lower dose and gradually titrated

• Dose adjustment is recommended in patients with renal impairment

Patients should follow their physician’s instructions carefully and should not stop the medication abruptly without medical advice.

Drug Interactions

Caution should be exercised when Numira Tablet 5 mg is used with:

• Alcohol

• Opioids

• Sedatives or other central nervous system depressants

Concurrent use may increase the risk of dizziness, somnolence, and impaired coordination.

Contraindications

Numira Tablet 5 mg is contraindicated in patients with known hypersensitivity to Mirogabalin Besylate or any component of the formulation.

Side Effects

Common side effects associated with Numira Tablet 5 mg may include:

• Dizziness

• Drowsiness or somnolence

• Headache

• Weight gain

• Peripheral edema

These adverse effects are generally mild to moderate and often decrease as treatment continues.

Pregnancy & Lactation

There is limited clinical data on the use of Mirogabalin during pregnancy and breastfeeding. Numira Tablet 5 mg should be used during pregnancy only if the potential benefits outweigh the potential risks. Caution is advised when prescribing to lactating women.

Precautions & Warnings

• Use with caution in patients with renal dysfunction

• Avoid activities requiring mental alertness if dizziness or drowsiness occurs

• Gradual dose reduction is recommended when discontinuing therapy to prevent withdrawal symptoms

Storage Conditions

Store in a cool and dry place, away from light and moisture. Keep out of the reach of children.