Aciphin Injection 500 mg contains Ceftriaxone Sodium, a third-generation cephalosporin antibiotic widely used to treat a variety of bacterial infections. Ceftriaxone works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Its broad-spectrum activity makes it effective against both Gram-positive and Gram-negative bacteria, making it suitable for respiratory, urinary, skin, bone, joint, and systemic infections.

This injectable formulation provides rapid therapeutic action via intravenous or intramuscular administration, ensuring high bioavailability and prompt symptom relief in both mild and severe infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Aciphin Injection 500 mg is indicated for the treatment of:

• Respiratory tract infections such as pneumonia and bronchitis
• Urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Meningitis caused by susceptible bacteria
• Septicemia and other systemic bacterial infections
• Sexually transmitted infections like gonorrhea caused by susceptible organisms

Mechanism of Action

Ceftriaxone is a bactericidal antibiotic that:

• Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins
• Causes lysis and death of susceptible bacteria
• Provides broad-spectrum activity against aerobic and anaerobic bacteria

This results in rapid elimination of pathogenic bacteria and resolution of infection.

Dosage and Administration

• Adults: Typically 500 mg to 2 g daily depending on the severity of infection; may be administered as a single daily dose or divided doses.
• Children: Dosage is weight-based as prescribed by a physician.
• Route: Administered intravenously (IV) or intramuscularly (IM).
  • For IM injection, reconstitute with a suitable sterile solution.
  • For IV infusion, dilute in 50–100 ml of compatible fluid and infuse over 30 minutes.
• Complete the full course of therapy even if symptoms improve to prevent bacterial resistance.

Side Effects

Common side effects include:

• Pain, swelling, or redness at the injection site
• Nausea, vomiting, or diarrhea
• Mild skin rash or itching

Rare but serious side effects:

• Severe allergic reactions, including anaphylaxis
• Hematologic abnormalities (e.g., leukopenia, thrombocytopenia)
• Liver enzyme elevations or hepatitis
• Clostridium difficile-associated diarrhea

Seek immediate medical attention for severe or persistent symptoms.

Precautions and Warnings

• Use with caution in patients with a history of penicillin or cephalosporin allergy.
• Monitor renal and hepatic function during prolonged therapy.
• Adjust dose in patients with kidney or liver impairment.
• Not effective against viral infections such as the common cold or flu.
• Report signs of severe diarrhea, jaundice, or hypersensitivity reactions promptly.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Aciphin Injection may interact with:

• Aminoglycoside antibiotics – increased risk of nephrotoxicity
• Anticoagulants – may enhance anticoagulant effect
• Live bacterial vaccines – may reduce efficacy
• Loop diuretics – potential for kidney impairment

Always inform your physician about concurrent medications.

Storage Instructions

• Store at 2–8°C (refrigerated)
• Protect from light and moisture
• Keep the vial tightly closed until use
• Do not freeze
• Keep out of reach of children.