Obecol Tablet 10 mg contains Obeticholic Acid, a selective farnesoid X receptor (FXR) agonist used in the management of chronic cholestatic liver diseases, particularly primary biliary cholangitis (PBC). It is typically prescribed in patients who require a higher maintenance dose after initial therapy with lower-strength Obeticholic Acid or in those who do not achieve adequate response with standard treatment options. Obecol helps improve bile flow, reduce liver inflammation, and slow disease progression under specialist supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Obeticholic Acid 10 mg

Mechanism of Action

Obeticholic Acid works by activating the farnesoid X receptor (FXR), a key regulator of bile acid synthesis and transport. Activation of FXR decreases the production of bile acids in the liver while enhancing their excretion. This reduces toxic bile acid accumulation, thereby protecting liver cells, reducing inflammation, and helping to slow fibrosis progression in chronic liver disease.

Indications

Obecol Tablet 10 mg is indicated for:

• Primary biliary cholangitis (PBC)
• Chronic cholestatic liver disease (specialist-directed therapy)
• Patients requiring dose escalation after initial Obeticholic Acid therapy
• Combination therapy with ursodeoxycholic acid in inadequate responders

Dosage and Administration

• Must be used under the supervision of a hepatologist or qualified physician.
• Dose is individualized based on liver function tests and clinical response.
• Taken orally with or without food.
• Regular monitoring of liver enzymes and clinical status is essential.
• Do not discontinue or adjust dosage without medical advice.

Benefits

• Helps slow progression of liver fibrosis in PBC
• Improves bile acid regulation and liver function
• Reduces liver inflammation and cholestasis
• Supports long-term management of chronic liver disease
• Useful in patients requiring higher-dose therapy under supervision

Side Effects

Common side effects may include:

• Itching (pruritus)
• Fatigue
• Abdominal discomfort
• Joint pain
• Rash

Serious but rare side effects:

• Worsening liver function in advanced liver disease
• Elevated liver enzymes
• Hepatic decompensation in at-risk patients
• Severe hypersensitivity reactions

Close monitoring is required during therapy.

Precautions and Warnings

• Not recommended in patients with decompensated cirrhosis without specialist supervision.
• Use caution in patients with moderate to severe liver impairment.
• Regular liver function monitoring is mandatory.
• Dose adjustment may be required based on tolerance and response.
• Pregnancy and breastfeeding should only be considered if clearly advised by a physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Obecol may interact with:

• Bile acid sequestrants (e.g., cholestyramine, colesevelam)
• Drugs affecting liver metabolism (CYP-related interactions)
• Hepatotoxic medications
• Fat-soluble vitamin absorption may be affected in long-term use

Always inform your healthcare provider about all ongoing medications and supplements.

Storage

• Store below 30°C in a cool, dry place
• Protect from moisture and direct sunlight
• Keep out of reach of children.