Olic Tablet 5 mg contains Obeticholic Acid, a potent farnesoid X receptor (FXR) agonist used in the treatment of chronic liver conditions, particularly primary biliary cholangitis (PBC). PBC is a progressive autoimmune disease that causes inflammation and destruction of the bile ducts, leading to impaired bile flow, accumulation of toxic bile acids in the liver, and eventual liver damage. Olic Tablet 5 mg works by regulating bile acid production, reducing liver inflammation, and slowing disease progression.

Obeticholic Acid is specifically indicated for patients who have an inadequate response to standard therapy or cannot tolerate other treatments such as ursodeoxycholic acid (UDCA). By targeting the FXR pathway, it helps restore liver function, improve biochemical markers, and support overall liver health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Olic Tablet 5 mg is indicated for:

• Primary Biliary Cholangitis (PBC) in adults

• Patients with inadequate response or intolerance to ursodeoxycholic acid (UDCA)

• Reducing liver inflammation and bile acid accumulation in chronic cholestatic liver disease

• Supportive therapy to slow progression of liver fibrosis and preserve liver function

Mechanism of Action

Obeticholic Acid acts as a selective agonist of the farnesoid X receptor (FXR), a nuclear receptor involved in bile acid regulation:

1. FXR Activation: Stimulates FXR in the liver and intestines to reduce bile acid synthesis.

2. Bile Acid Regulation: Decreases the accumulation of toxic bile acids, which reduces hepatocyte injury.

3. Anti-inflammatory Effect: Modulates inflammatory pathways in the liver, helping to prevent progression of fibrosis.

4. Liver Protection: Improves liver function tests such as alkaline phosphatase (ALP) and bilirubin levels, which are key markers of PBC progression.

This targeted action addresses both the cause and consequences of bile acid buildup, providing meaningful therapeutic benefit for patients with chronic cholestatic liver disease.

Dosage and Administration

• Recommended dose: Usually 5 mg once daily, taken orally. The dose may be adjusted by a physician based on response and tolerance.

• Take the tablet with or without food at the same time each day.

• Regular monitoring of liver function tests is recommended to assess response and safety.

• Ensure adherence to therapy, as discontinuation may lead to worsening of liver function.

Precautions and Warnings

• Use with caution in patients with severe liver impairment or cirrhosis.

• Monitor for pruritus (itching), a common side effect associated with FXR agonists.

• Not recommended during pregnancy or breastfeeding unless advised by a physician.

• Dose adjustments may be required in patients with moderate to severe hepatic impairment.

• Avoid combining with other bile acid-lowering medications without medical supervision.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Itching (pruritus)

• Fatigue or weakness

• Abdominal discomfort

• Mild nausea

Rare but serious side effects may include liver function deterioration or worsening cholestasis. Immediate medical consultation is recommended if severe symptoms occur.

Storage

Store below 30°C in a dry, cool place, protected from light and moisture. Keep out of reach of children.

Olic Tablet 5 mg provides effective targeted therapy for primary biliary cholangitis, helping to regulate bile acids, reduce liver inflammation, and slow disease progression in patients who require additional or alternative treatment options.