Opton 40 mg contains Esomeprazole, a proton pump inhibitor (PPI) that effectively reduces gastric acid secretion. It is widely used in the management of acid-related gastrointestinal disorders by providing sustained acid suppression, promoting mucosal healing, and relieving symptoms associated with excessive stomach acid production.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Indications

Opton 40 mg is indicated for:

• Gastroesophageal Reflux Disease (GERD) and associated symptoms such as persistent heartburn and acid regurgitation

• Treatment and maintenance of healing of erosive esophagitis

• Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease when used in combination with amoxicillin and clarithromycin

• Zollinger–Ellison syndrome and other pathological hypersecretory conditions

• Duodenal and gastric ulcers caused by acid dyspepsia

• Acid-related dyspepsia

Dosage and Administration

• Erosive Esophagitis (Healing): 20–40 mg once daily for 4–8 weeks

• Maintenance of Healing: 20 mg once daily

• Symptomatic GERD: 20 mg once daily for 4 weeks

• H. pylori Eradication (Triple Therapy):

  • Esomeprazole 40 mg once daily

  • Amoxicillin 1000 mg twice daily

  • Clarithromycin 500 mg twice daily for 10 days

• Zollinger–Ellison Syndrome: 20–80 mg once daily, adjusted individually

• Duodenal Ulcer: 20 mg once daily for 2–4 weeks

• Gastric Ulcer: 20–40 mg once daily for 4–8 weeks

Opton 40 mg should be taken at least one hour before meals and swallowed whole. For patients unable to swallow capsules, the contents may be mixed with soft, cold applesauce and consumed immediately without chewing.

Mode of Action

Esomeprazole works by selectively inhibiting the H⁺/K⁺-ATPase enzyme (proton pump) in gastric parietal cells. This action blocks the final step of acid production, resulting in significant and prolonged suppression of gastric acid secretion. As the S-isomer of omeprazole, esomeprazole offers improved pharmacokinetic properties and enhanced acid control compared to racemic PPIs.

Drug Interactions

Esomeprazole is metabolized primarily by CYP2C19 and CYP3A4 enzymes. It may reduce the absorption of drugs dependent on gastric pH such as ketoconazole, iron salts, and digoxin. Caution is advised when co-administered with diazepam and other CYP2C19 substrates.

Contraindications

Opton 40 mg is contraindicated in patients with known hypersensitivity to esomeprazole or any component of the formulation.

Side Effects

Commonly reported side effects include:

• Headache

• Diarrhea

• Nausea

• Flatulence

• Abdominal pain

• Constipation

• Dry mouth

Long-term use up to 12 months has not shown significant differences in the type of adverse effects compared to short-term therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Symptomatic improvement does not exclude the possibility of gastric malignancy

• Use with caution in patients with severe hepatic impairment

• Antacids may be used concomitantly if required

Storage Conditions

Store in a dry place below 30°C. Protect from moisture and light. Keep out of reach of children.