Periset Tablet 8 mg contains Ondansetron, a highly selective 5-HT3 receptor antagonist used to prevent and treat nausea and vomiting caused by chemotherapy, radiotherapy, or surgical procedures. Ondansetron works by blocking serotonin (5-HT3) receptors in the central nervous system and gastrointestinal tract, which play a key role in triggering the vomiting reflex.

This oral tablet formulation provides a convenient and effective option for patients who require antiemetic therapy but prefer non-invasive administration. Periset Tablet 8 mg ensures rapid absorption and sustained action, helping control both acute and delayed episodes of nausea and vomiting, improving patient comfort and compliance with treatment regimens.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Prevents chemotherapy-induced nausea and vomiting (CINV)

• Reduces radiotherapy-induced nausea and vomiting (RINV)

• Controls postoperative nausea and vomiting (PONV)

• Oral tablet offers convenient, non-invasive administration

• Rapid onset of action with effective symptom control

• Improves patient comfort, adherence to therapy, and quality of life

Mechanism of Action

Ondansetron, the active ingredient in Periset Tablet, works as a selective 5-HT3 receptor antagonist:

1. Serotonin Receptor Blockade:

   • Chemotherapy, radiotherapy, or surgical stress triggers serotonin release from enterochromaffin cells in the gastrointestinal tract.

   • Serotonin binds to 5-HT3 receptors on vagal nerve endings, activating the vomiting center in the brain.

   • Ondansetron blocks these receptors, preventing nausea and vomiting signals from reaching the brain.

2. Peripheral and Central Action:

   • Acts on 5-HT3 receptors in both the gut and central nervous system, providing comprehensive antiemetic protection.

3. Rapid Absorption and Sustained Effect:

   • Oral administration allows for quick absorption, providing fast relief from nausea and vomiting.

   • Maintains effective plasma levels to prevent both acute (0–24 hours) and delayed (24–120 hours) nausea.

Indications

Periset Tablet 8 mg is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderate or highly emetogenic chemotherapy

• Prevention of radiotherapy-induced nausea and vomiting (RINV)

• Prevention and management of postoperative nausea and vomiting (PONV)

• Suitable for adult patients requiring oral antiemetic therapy

Dosage and Administration

• Adults: 8 mg orally 30 minutes before chemotherapy or surgery, or as prescribed by a physician.

• Pediatrics: Dose should be adjusted based on body weight and clinical judgment, and only administered under medical supervision.

• Can be taken with or without food.

• Swallow the tablet whole with water; do not crush or chew.

• Follow the prescribed dosing schedule to ensure optimal antiemetic effect.

Precautions and Warnings

• Use with caution in patients with cardiac arrhythmias or prolonged QT interval.

• Avoid in patients with known hypersensitivity to Ondansetron or other 5-HT3 antagonists.

• Monitor patients taking other drugs that prolong the QT interval.

• Pregnant and breastfeeding women should use only under medical supervision.

• Dose adjustment may be required in patients with hepatic impairment.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Periset Tablet is generally well-tolerated. Common side effects include:

• Headache

• Constipation or diarrhea

• Fatigue or dizziness

• Rare allergic reactions or arrhythmias

Seek medical attention if severe reactions such as rash, swelling, or difficulty breathing occur.

Storage

Store below 30°C in a cool, dry place, protected from light. Keep out of reach of children.

Periset Tablet 8 mg provides effective, fast-acting prevention of nausea and vomiting, making it a reliable oral option for patients undergoing chemotherapy, radiotherapy, or surgery.