Pime-4 Injection 1 gm/vial contains Cefepime Hydrochloride, a fourth-generation cephalosporin antibiotic with broad-spectrum bactericidal activity. It is used for the treatment of severe bacterial infections caused by susceptible Gram-positive and Gram-negative organisms. Cefepime is particularly effective against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Enterobacteriaceae. Pime-4 is commonly used in hospital settings for respiratory tract infections, urinary tract infections, skin infections, intra-abdominal infections, septicemia, and febrile neutropenia.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Cefepime Hydrochloride 1 gm (sterile lyophilized powder for injection)

Mechanism of Action

Cefepime, a beta-lactam antibiotic, acts by:

• Inhibiting bacterial cell wall synthesis
• Binding to penicillin-binding proteins (PBPs)
• Causing bacterial cell lysis and death

Its bactericidal action provides rapid eradication of pathogens and broad coverage against both Gram-positive and Gram-negative bacteria.

Indications

Pime-4 Injection is indicated for:

• Severe lower and upper respiratory tract infections (pneumonia, bronchitis)
• Complicated urinary tract infections
• Skin and soft tissue infections
• Intra-abdominal infections
• Septicemia and bacteremia
• Febrile neutropenia in immunocompromised patients

Dosage and Administration

• Administer intravenously or intramuscularly as directed by a healthcare professional.
• Dosage depends on infection severity, renal function, and patient age.
• Reconstitute with appropriate diluents following guidelines.
• Typically administered every 12 hours; severe infections may require adjusted dosing.
• Monitor renal function and clinical response throughout therapy.

Benefits

• Broad-spectrum antibacterial coverage
• Effective against multidrug-resistant Gram-negative and Gram-positive bacteria
• Rapid bactericidal activity
• Suitable for severe and complicated infections
• Flexible dosing options for adults and pediatric patients

Side Effects

Common side effects may include:

• Pain, redness, or swelling at the injection site
• Nausea or vomiting
• Diarrhea
• Headache

Serious side effects (rare) may include:

• Severe hypersensitivity reactions, including anaphylaxis
• Seizures in patients with renal impairment
• Clostridium difficile-associated diarrhea

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Assess for penicillin or cephalosporin allergy before administration.
• Dose adjustment required in renal impairment.
• Monitor for superinfections with prolonged use.
• Use cautiously in neonates and elderly patients.
• Ensure adequate hydration to minimize renal risk.

Storage

• Store lyophilized powder below 25°C in a dry place
• Protect from light and moisture
• Reconstituted solution should be used immediately or stored as recommended
• Keep out of reach of children.