Pulmidone Tablet 801 mg contains Pirfenidone, an antifibrotic and anti-inflammatory agent used in the treatment of Idiopathic Pulmonary Fibrosis (IPF). IPF is a chronic, progressive, and irreversible lung disease characterized by scarring of lung tissue, leading to a gradual decline in lung function. Pulmidone 801 mg helps slow disease progression, preserve lung capacity, and improve long-term clinical outcomes in patients diagnosed with IPF.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Pulmidone Tablet 801 mg is indicated for:

• Idiopathic Pulmonary Fibrosis (IPF):
  To reduce the rate of decline in lung function and slow the progression of fibrotic changes in the lungs.

Therapeutic Class

Antifibrotic agent

Pharmacology

Pirfenidone, the active ingredient of Pulmidone Tablet 801 mg, exhibits antifibrotic, anti-inflammatory, and antioxidant properties. Although its exact mechanism is not fully understood, pirfenidone is known to inhibit the synthesis of profibrotic cytokines, particularly transforming growth factor-beta (TGF-β) and tumor necrosis factor-alpha (TNF-α). By modulating these pathways, Pulmidone 801 mg reduces fibroblast proliferation and collagen formation, thereby limiting lung tissue scarring and preserving pulmonary function.

Dosage and Administration

• Pulmidone Tablet 801 mg is usually administered three times daily with food as part of a maintenance regimen.

• Treatment is typically initiated with a gradual dose titration to minimize gastrointestinal side effects.

• Tablets should be swallowed whole and taken at evenly spaced intervals throughout the day.

• Long-term and continuous treatment is recommended to maintain therapeutic benefits unless otherwise advised by a physician.

Drug Interactions

• Strong inhibitors of CYP1A2 (such as fluvoxamine) may significantly increase pirfenidone plasma concentrations and should be avoided.

• Moderate CYP1A2 inhibitors (such as ciprofloxacin) may require dose adjustment.

• Smoking may reduce pirfenidone exposure and is not recommended during therapy.

• Patients should inform their healthcare provider of all medications, supplements, or herbal products they are using.

Contraindications

• Hypersensitivity to pirfenidone or any component of the formulation.

• Severe hepatic impairment or end-stage liver disease.

• Concomitant use with strong CYP1A2 inhibitors.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Pulmidone Tablet 801 mg is generally well tolerated, with most side effects being mild to moderate and manageable. Common adverse reactions include:

• Nausea and vomiting

• Diarrhea

• Loss of appetite

• Fatigue

• Dizziness

• Photosensitivity reactions and skin rash

Liver enzyme elevations may occur; therefore, routine liver function monitoring is recommended.

Pregnancy and Lactation

There is limited data on the use of pirfenidone during pregnancy. Pulmidone Tablet 801 mg should be used during pregnancy only if clearly needed and prescribed by a physician.
It is not known whether pirfenidone is excreted in human milk; therefore, a decision should be made to discontinue breastfeeding or the medication, considering the importance of therapy to the mother.

Precautions and Warnings

• Liver function tests should be performed before initiating treatment and periodically thereafter.

• Patients should avoid excessive sun exposure and use appropriate sun protection due to the risk of photosensitivity.

• Smoking cessation is strongly advised, as smoking may reduce drug effectiveness.

• Dose adjustment may be required in patients with hepatic or renal impairment.

Storage Conditions

Store in a cool, dry place away from direct light and moisture.
Keep out of the reach of children.

Mode of Action

Pulmidone Tablet 801 mg acts by inhibiting key fibrotic and inflammatory pathways involved in the development of idiopathic pulmonary fibrosis. By reducing fibroblast activity and collagen deposition, it helps slow lung scarring and preserves respiratory function.