Oxiplat Injection 5 mg/ml contains Oxaliplatin, a platinum-based chemotherapeutic agent used in the treatment of various types of cancer, most notably colorectal cancer. Oxaliplatin belongs to the class of alkylating agents, which work by binding to DNA in cancer cells, forming cross-links that inhibit DNA replication and transcription. This leads to cell cycle arrest and apoptosis, effectively reducing tumor growth.

The injection is designed for intravenous administration, allowing the medication to be delivered directly into the bloodstream for systemic treatment of metastatic or advanced cancers. Oxiplat is often used in combination chemotherapy regimens, such as FOLFOX (Oxaliplatin, Fluorouracil, and Leucovorin), enhancing its anti-cancer efficacy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Oxiplat Injection 5 mg/ml is indicated for:

• Colorectal cancer: As part of first-line or adjuvant chemotherapy in metastatic or advanced disease.

• Gastrointestinal cancers: Often used in combination with other chemotherapeutic agents for stomach or pancreatic cancers, based on clinical judgment.

• Combination chemotherapy regimens: Used with fluoropyrimidines and leucovorin for enhanced tumor suppression.

The drug should only be administered under the supervision of an oncologist or trained medical professional experienced in chemotherapy.

Key Benefits

• Potent anti-cancer activity: Oxaliplatin effectively inhibits tumor growth by disrupting DNA replication.

• Synergistic effect: Highly effective in combination regimens, improving patient outcomes in colorectal cancer.

• Systemic administration: IV delivery ensures widespread distribution to target tumor cells throughout the body.

• Clinical evidence: Proven efficacy in reducing recurrence risk and improving progression-free survival in colorectal cancer patients.

• Versatile use: Can be used in both adjuvant therapy and treatment of metastatic disease.

Oxiplat Injection 5 mg/ml provides an essential component in modern chemotherapeutic protocols, offering significant benefits in cancer management.

Dosage and Administration

• Adults: Dosage is typically calculated based on body surface area (mg/m²) and given intravenously, often in combination with other chemotherapeutic agents.

• Administer slowly via IV infusion over several hours to reduce the risk of adverse effects.

• Dose frequency is usually every 2–3 weeks, depending on the specific chemotherapy regimen.

• Close monitoring of blood counts, kidney and liver function, and neurological status is essential during treatment.

• Hydration before and after administration is recommended to reduce renal toxicity.

Dosage adjustments may be necessary in patients with hepatic or renal impairment, or those experiencing severe side effects.

Precautions

• Not suitable for patients with severe hypersensitivity to platinum compounds.

• Use caution in patients with pre-existing neuropathy, kidney, or liver disorders.

• Pregnancy and breastfeeding are contraindicated due to potential fetal toxicity.

• Monitor for electrolyte disturbances, myelosuppression, and neuropathic symptoms during therapy.

• Administer only in a hospital or clinic setting equipped to manage chemotherapy complications.

Possible Side Effects

Common side effects include:

• Peripheral neuropathy (numbness, tingling, or pain in hands and feet)

• Nausea, vomiting, or diarrhea

• Fatigue and weakness

• Myelosuppression (low blood counts)

• Cold sensitivity and pharyngolaryngeal discomfort

Serious but less common effects may include allergic reactions, liver toxicity, severe infections due to immunosuppression, or rare cardiac effects. Immediate medical attention is required if severe reactions occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store at 2–8°C in a refrigerator; do not freeze.

• Protect from light; keep the vial in its original packaging until use.

• Keep out of reach of children.

• Use immediately after preparation, following aseptic techniques.

• Do not use if the solution is discolored or contains particles.

Oxiplat Injection 5 mg/ml (Oxaliplatin) is a critical chemotherapeutic agent for the treatment of colorectal and other gastrointestinal cancers. With proper dosing, monitoring, and combination therapy, it significantly contributes to tumor control and improved survival outcomes in cancer patients.