Ribolib Tablet 200 mg contains Ribociclib, a selective cyclin-dependent kinase (CDK) 4/6 inhibitor used in the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) advanced or metastatic breast cancer. It is used in combination with endocrine therapy to slow cancer cell growth and improve treatment outcomes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Ribociclib 200 mg

Mechanism of Action

Ribociclib works by selectively inhibiting CDK4 and CDK6 enzymes, which are essential for cell cycle progression. Its actions include:

• Blocking phosphorylation of retinoblastoma (Rb) protein
• Preventing transition from G1 to S phase of the cell cycle
• Slowing proliferation of cancer cells
• Enhancing effectiveness of endocrine (hormonal) therapy

Indications

Ribolib Tablet is indicated for:

• HR-positive, HER2-negative advanced or metastatic breast cancer
• First-line treatment in combination with aromatase inhibitors or fulvestrant
• Postmenopausal or premenopausal women (with ovarian suppression as required)

Dosage and Administration

• To be taken strictly under the supervision of an oncologist
• Usually administered once daily for 21 days followed by 7 days off (28-day cycle)
• Can be taken with or without food
• Tablet should be swallowed whole with water
• Dose may be adjusted based on blood counts and tolerability

Benefits

• Slows progression of hormone receptor-positive breast cancer
• Enhances effectiveness of hormonal therapy
• Helps delay disease progression
• Improves progression-free survival in many patients
• Oral therapy offers convenient administration

Side Effects

Common side effects may include:

• Neutropenia (low white blood cells)
• Fatigue
• Nausea
• Diarrhea or constipation
• Hair thinning
• Liver enzyme elevation

Serious effects may include infection risk and cardiac rhythm changes (QT prolongation).

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Regular blood count and liver function monitoring is required
• ECG monitoring may be needed due to QT prolongation risk
• Use cautiously in patients with liver or heart disease
• Not recommended during pregnancy or breastfeeding
• Inform doctor about all medications to avoid interactions

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.