Rofuclav Tablet 500 mg + 125 mg is a combination antibiotic containing Cefuroxime Axetil and Clavulanic Acid, designed to effectively treat a wide range of bacterial infections. This dual-action formulation enhances the antibacterial activity against resistant bacteria and helps improve treatment outcomes. It is commonly prescribed for infections affecting the respiratory tract, urinary tract, skin, soft tissues, and ear, nose, and throat (ENT).

Cefuroxime Axetil belongs to the second-generation cephalosporin antibiotic class. It works by interfering with the formation of the bacterial cell wall, which is essential for bacterial survival. By weakening the cell wall structure, Cefuroxime causes bacteria to rupture and die, thereby eliminating the infection.

Clavulanic Acid is a beta-lactamase inhibitor that enhances the effectiveness of Cefuroxime. Some bacteria produce enzymes called beta-lactamases, which can break down certain antibiotics and make them ineffective. Clavulanic Acid blocks these enzymes, allowing Cefuroxime to remain active and effectively destroy the bacteria. This combination broadens the spectrum of activity and helps combat antibiotic-resistant strains.

Rofuclav Tablet is widely used in the treatment of bacterial infections where single antibiotics may not be sufficient. Its dual-action mechanism provides improved antibacterial coverage and helps ensure more reliable treatment results.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antibiotic

• Second-generation cephalosporin with beta-lactamase inhibitor

Composition

Each film-coated tablet contains:

• Cefuroxime Axetil – 500 mg

• Clavulanic Acid – 125 mg

This combination provides enhanced antibacterial activity against a wide range of susceptible bacteria.

Indications

Rofuclav Tablet 500 mg + 125 mg is indicated for the treatment of various bacterial infections, including:

• Respiratory tract infections such as bronchitis and pneumonia

• Ear, nose, and throat infections including sinusitis, tonsillitis, and otitis media

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Certain bacterial infections resistant to standard antibiotics

A healthcare professional determines the appropriate use based on the type and severity of infection.

Mechanism of Action

The combination works through two complementary mechanisms:

• Cefuroxime Axetil inhibits bacterial cell wall synthesis, causing bacteria to weaken and die.

• Clavulanic Acid protects Cefuroxime from destruction by beta-lactamase enzymes produced by resistant bacteria.

Together, they enhance antibacterial effectiveness and help treat infections caused by beta-lactamase-producing organisms.

Dosage and Administration

• The usual dose is one tablet as prescribed by a physician, typically taken once or twice daily depending on the infection.

• Tablets should be taken after meals to improve absorption and reduce stomach discomfort.

• The full course of treatment should be completed even if symptoms improve earlier.

Always follow the dosage instructions provided by a healthcare professional.

Possible Side Effects

Common side effects may include:

• Nausea or vomiting

• Diarrhea

• Abdominal discomfort

• Headache

• Mild skin rash

Most side effects are mild and temporary. However, patients should seek medical advice if severe allergic reactions or persistent symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Inform your doctor if you are allergic to cephalosporin or penicillin antibiotics.

• Use with caution in patients with kidney or liver problems.

• Do not use this medication without a confirmed bacterial infection.

• Avoid self-medication and always complete the prescribed course to prevent antibiotic resistance.

Storage

Store below 30°C in a dry place away from direct sunlight and moisture. Keep the medication in its original packaging and out of reach of children.