Rostil 135 mg Tablet contains Mebeverine, a musculotropic antispasmodic used to relieve gastrointestinal spasms and discomfort. It is particularly effective in managing Irritable Bowel Syndrome (IBS), chronic irritable colon, colicky abdominal pain, mucous colitis, spastic constipation, and persistent non-specific diarrhea. By relaxing the smooth muscles of the gut, Rostil 135 mg helps restore normal bowel movements and alleviate pain without affecting normal gut motility.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Rostil 135 mg is indicated for the symptomatic relief of:

• Irritable Bowel Syndrome (IBS)

• Chronic irritable colon

• Spastic constipation

• Mucous colitis

• Colicky abdominal pain

• Persistent non-specific diarrhea

Therapeutic Class

Anticholinergics – Musculotropic Antispasmodic

Pharmacology

Mebeverine acts directly on the smooth muscles of the gastrointestinal tract, producing relaxation of spasms without affecting normal peristalsis. Unlike systemic anticholinergics, it does not have significant central nervous system effects. This targeted action helps reduce abdominal cramping, bloating, and discomfort associated with IBS and other functional gastrointestinal disorders.

Dosage and Administration

Adults, elderly, and children over 10 years:

• Rostil 135 mg Tablet: 1 tablet, 3 times daily

• Rostil 200 mg SR Capsule: 1 capsule, 2 times daily

Administration Guidelines:

• Most effective when taken 20 minutes before meals.

• After several weeks of use and symptom relief, dosage may be gradually reduced.

• If a dose is missed, take it as soon as possible, but do not double the next dose.

Use in children:

• Not recommended for children under 10 years.

Drug Interactions

• No significant drug interactions have been reported with Mebeverine.

Contraindications

• Hypersensitivity to Mebeverine or any of its ingredients.

Side Effects

• Generally well tolerated.

• Rarely, side effects such as skin rash, urticaria, or angioedema may occur.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

• No teratogenic effects observed in animal studies.

• Should be used during pregnancy only under medical supervision.

• Mebeverine is not excreted in breast milk at therapeutic doses, making it generally safe during lactation.

Precautions and Warnings

• Caution in patients with porphyria or a history of allergic reactions to anticholinergic drugs.

• Use with care in elderly patients or those with severe gastrointestinal disease.

Overdose

• CNS excitability may occur in case of overdose.

• No specific antidote exists; symptomatic treatment and gastric lavage are recommended.

Storage Conditions

• Store below 30°C, away from light and moisture.

• Keep out of reach of children.

Mode of Action

Mebeverine, the active ingredient in Rostil 135 mg, acts as a musculotropic antispasmodic. It relaxes the smooth muscle fibers of the gastrointestinal tract, reduces spasm-induced pain, and restores normal gut motility. Unlike classical anticholinergics, it does not interfere with normal bowel movements or central nervous system functions, making it safe for long-term symptomatic management of IBS and related disorders.