Rosutin 10 mg Tablet is a statin medication primarily used to manage high cholesterol levels and reduce the risk of cardiovascular disease. It contains Rosuvastatin, a potent HMG-CoA reductase inhibitor that lowers harmful cholesterol levels while supporting heart health. By reducing low-density lipoprotein cholesterol (LDL-C) and triglycerides and moderately increasing high-density lipoprotein cholesterol (HDL-C), Rosutin 10 mg helps prevent atherosclerosis, heart attacks, strokes, and other cardiovascular complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Rosutin 10 mg Tablet is indicated for:

• Heterozygous Hypercholesterolemia (familial and non-familial)

• Homozygous Hypercholesterolemia (familial)

• Mixed Dyslipidemia (Fredrickson Type IIa and IIb)

• Primary prevention of cardiovascular disease in patients with risk factors such as diabetes, hypertension, or a history of heart disease

Pharmacology and Mode of Action

Rosutin 10 mg is a selective and competitive inhibitor of HMG-CoA reductase, the enzyme responsible for converting HMG-CoA to mevalonate, a key step in cholesterol synthesis. Its lipid-lowering effect occurs through two main mechanisms:

1. Increased LDL receptor activity: Enhances hepatic uptake and catabolism of LDL cholesterol

2. Reduced VLDL synthesis: Lowers the total number of VLDL and LDL particles

This dual action effectively reduces total cholesterol, LDL-C, and triglycerides, while moderately increasing HDL-C.

Dosage and Administration

• Adults: 5–40 mg once daily; 40 mg is reserved for patients not achieving LDL-C goals with 20 mg

• Homozygous Familial Hypercholesterolemia (HoFH): Starting dose 20 mg/day

• Pediatric Use:

  • Heterozygous familial hypercholesterolemia (HeFH): 5–10 mg/day (ages 8–10), 5–20 mg/day (ages 10–17)

  • HoFH: 20 mg/day (ages 7–17)

Rosutin 10 mg can be taken with or without food, at any time of the day, for convenience and compliance.

Drug Interactions

• Cyclosporine: Maximum recommended dose 5 mg/day

• Gemfibrozil: Avoid combination; if necessary, limit dose to 10 mg/day

• Lopinavir/Ritonavir or Atazanavir/Ritonavir: Limit dose to 10 mg/day

• Coumarin anticoagulants: May prolong INR; monitor frequently

• Other lipid-lowering therapies: Increased risk of skeletal muscle effects

Contraindications

Rosutin 10 mg should not be used in patients with:

• Hypersensitivity to Rosuvastatin or its components

• Active liver disease or unexplained persistent elevations in hepatic transaminases

• Pregnancy or breastfeeding

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Rosutin 10 mg is generally well tolerated. Common adverse effects may include:

• Headache

• Myalgia or muscle pain

• Constipation

• Fatigue (asthenia)

• Abdominal discomfort or nausea

Precautions and Warnings

• Muscle-related effects: Myopathy and rhabdomyolysis risk increases with high doses (40 mg), advanced age, hypothyroidism, renal impairment, or combination with certain drugs

• Liver function monitoring: Liver enzymes should be checked before starting and periodically during therapy

• Promptly report muscle pain or weakness to prevent serious complications

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.

Special Populations

• Safety and effectiveness in pediatric patients are not established

• Adjust monitoring and dosage in patients with predisposing conditions for adverse effects.