Sacutan Tablet 97 mg + 103 mg combines Sacubitril and Valsartan, a dual-action therapy designed for the treatment of heart failure with reduced ejection fraction (HFrEF). Sacubitril is a neprilysin inhibitor that enhances levels of beneficial natriuretic peptides, promoting vasodilation, reducing fluid retention, and limiting harmful cardiac remodeling. Valsartan is an angiotensin II receptor blocker (ARB) that relaxes blood vessels, lowers blood pressure, and reduces the workload on the heart.

This combination, classified as an angiotensin receptor-neprilysin inhibitor (ARNI), addresses the neurohormonal and hemodynamic mechanisms of heart failure. Sacutan Tablet 97 mg + 103 mg is typically used as a higher maintenance dose for patients who have tolerated the lower doses (24 mg + 26 mg and 49 mg + 51 mg) and require optimal long-term therapy. It improves cardiac output, reduces heart failure symptoms, and lowers the risk of hospitalization and cardiovascular-related mortality.

By targeting both pathways—blocking harmful angiotensin II effects and enhancing protective natriuretic peptides—Sacutan supports improved heart function, reduces fluid overload, and helps patients maintain a more active and independent lifestyle.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Symptom Relief: Reduces shortness of breath, fatigue, swelling, and fluid retention associated with chronic heart failure.

• Improves Cardiac Function: Helps restore effective heart pumping and reduces cardiac remodeling.

• Decreases Hospitalization Risk: Lowers the chance of recurrent heart failure admissions.

• Cardiovascular Protection: Reduces the risk of cardiovascular death in patients with HFrEF.

• Dual Mechanism of Action: Combines neprilysin inhibition and ARB therapy for comprehensive heart failure management.

Indications

Sacutan Tablet 97 mg + 103 mg is indicated for:

• Chronic heart failure with reduced ejection fraction (HFrEF)

• Maintenance therapy for patients stabilized on lower Sacutan doses

• Prevention of recurrent heart failure-related hospitalizations

• Symptomatic patients requiring optimal long-term ARNI therapy

This higher-dose formulation is suitable for patients who require maximum therapeutic effect while being carefully monitored by a healthcare professional.

Dosage and Administration

The usual dose is one tablet orally twice daily, with or without food, as prescribed by a doctor.

• Swallow the tablet whole; do not crush or chew.

• Take consistently at the same time each day to maintain stable blood levels.

• Regular monitoring of blood pressure, kidney function, and electrolytes is essential during therapy.

Dose adjustments may be necessary in patients with kidney impairment, low blood pressure, or other health conditions.

Possible Side Effects

Sacutan Tablet 97 mg + 103 mg is generally well tolerated, but some patients may experience:

• Low blood pressure (hypotension)

• Dizziness or lightheadedness

• Cough

• Elevated potassium levels (hyperkalemia)

• Changes in kidney function

Rare but serious side effects may include severe hypotension, angioedema, or worsening kidney function. Immediate medical attention is required if severe symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Do not use concurrently with ACE inhibitors to reduce the risk of angioedema.

• Inform your doctor if you have kidney or liver disease, low blood pressure, or high potassium levels.

• Pregnant or breastfeeding women should avoid this medication.

• Disclose all other medications to prevent potential drug interactions.

Storage

Store Sacutan Tablet 97 mg + 103 mg in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.