Salflu Inhalation Capsule 50 mcg+250 mcg is a high-potency combination of Salmeterol 50 mcg, a long-acting beta-2 adrenergic agonist (LABA), and Fluticasone Propionate 250 mcg, an inhaled corticosteroid (ICS). This formulation is designed for long-term management of moderate to severe asthma and chronic obstructive pulmonary disease (COPD), providing both bronchodilatory and anti-inflammatory effects in a single therapy.

Salmeterol works by relaxing the smooth muscles in the airways, ensuring improved airflow, while Fluticasone Propionate reduces airway inflammation, edema, and mucus production, preventing exacerbations and improving lung function. The combination is particularly suitable for patients whose symptoms are not adequately controlled with inhaled corticosteroid monotherapy, offering enhanced control and better quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each inhalation capsule contains:

• Salmeterol 50 mcg

• Fluticasone Propionate 250 mcg

• Inactive ingredients to stabilize the powder and ensure effective delivery via a dry powder inhaler (DPI)

Indications

Salflu Inhalation Capsule 50 mcg+250 mcg is indicated for:

• Maintenance therapy in moderate to severe asthma in adults and adolescents

• Prevention of bronchospasm and reduction of asthma exacerbations

• Long-term management of COPD to improve airflow and reduce symptom frequency

• Patients inadequately controlled on lower-dose inhaled corticosteroids

• Improvement of quality of life in individuals with persistent respiratory symptoms

Mechanism of Action

The combination of Salmeterol and Fluticasone Propionate provides complementary benefits:

1. Salmeterol (Long-acting beta-2 agonist):

   • Stimulates beta-2 adrenergic receptors in bronchial smooth muscle

   • Induces long-lasting bronchodilation, reducing wheezing, breathlessness, and chest tightness

   • Duration of action up to 12 hours, supporting twice-daily dosing

2. Fluticasone Propionate (Inhaled corticosteroid):

   • Suppresses airway inflammation by inhibiting inflammatory cells and mediators

   • Reduces airway edema, mucus secretion, and hyperresponsiveness

   • Prevents airway remodeling and decreases frequency of asthma attacks

Together, the combination ensures controlled airway patency and reduced inflammation, improving respiratory function and preventing acute exacerbations.

Dosage and Administration

• Adults and adolescents: 1 capsule inhaled twice daily using a dry powder inhaler (DPI)

• Capsules should be inhaled at the same time each day for consistent therapeutic effect

• Not to be used as a rescue inhaler for sudden asthma attacks; a short-acting bronchodilator should be used in emergencies

• Rinse mouth after inhalation to prevent oral thrush and irritation

• Regular monitoring of lung function, symptoms, and inhaler technique is recommended

Precautions and Warnings

• Not intended for acute bronchospasm

• Use caution in patients with heart disease, hypertension, diabetes, or thyroid disorders

• Avoid abrupt discontinuation of Fluticasone to prevent adrenal insufficiency

• Report any paradoxical bronchospasm, worsening symptoms, or allergic reactions immediately

• Pediatric, elderly, or pregnant patients should use under strict medical supervision

Possible Side Effects

Salflu Inhalation Capsule 50 mcg+250 mcg is generally well tolerated. Common side effects include:

• Throat irritation or hoarseness

• Oral candidiasis (thrush)

• Headache

• Tremors or palpitations (rare, due to Salmeterol)

• Rare systemic corticosteroid effects such as adrenal suppression

Most side effects are mild and preventable with proper inhalation technique and mouth rinsing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Keep out of reach of children

• Do not swallow or puncture capsules

Conclusion

Salflu Inhalation Capsule 50 mcg+250 mcg (Salmeterol + Fluticasone Propionate) provides effective maintenance therapy for patients with moderate to severe asthma and COPD. Its dual action ensures bronchodilation and anti-inflammatory control, reducing exacerbations, improving lung function, and enhancing quality of life. Regular use under physician guidance, along with proper inhaler technique, ensures optimal respiratory health.