Sefril Capsule 500 mg is an oral antibiotic formulation containing Cephradine, a first-generation cephalosporin effective against a wide range of bacterial infections. It is commonly prescribed for respiratory tract infections, urinary tract infections, skin and soft tissue infections, and ear infections, offering a convenient and reliable oral therapy.

Cephradine works by inhibiting bacterial cell wall synthesis, leading to the death of susceptible bacteria. Sefril 500 mg provides a higher dose option, which is suitable for moderate to severe infections or infections caused by bacteria requiring enhanced antimicrobial coverage. Its oral administration ensures rapid absorption and systemic action, making it ideal for outpatient treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each capsule contains:

• Cephradine 500 mg

• Inactive ingredients to ensure capsule stability, absorption, and efficacy

Indications

Sefril Capsule 500 mg is indicated for the treatment of infections caused by susceptible bacteria, including:

• Respiratory tract infections: pharyngitis, tonsillitis, bronchitis, and pneumonia

• Skin and soft tissue infections: cellulitis, abscesses, and wound infections

• Urinary tract infections: cystitis, pyelonephritis, and urethritis

• Ear infections: otitis media

• Bone and joint infections caused by susceptible organisms

• Prevention of infections in certain surgical procedures

Mechanism of Action

Cephradine is a beta-lactam antibiotic that works by:

• Binding to penicillin-binding proteins (PBPs) in the bacterial cell wall

• Inhibiting the final step of cell wall synthesis, which leads to bacterial lysis

• Exhibiting bactericidal activity against actively dividing bacteria

• Targeting Gram-positive bacteria such as Staphylococcus aureus and Streptococcus species, and selected Gram-negative bacteria like Escherichia coli, Klebsiella, and Proteus species

Its oral bioavailability ensures effective systemic concentrations, making it suitable for treating a variety of infections.

Dosage and Administration

• Adults: 500 mg orally every 12 hours, or as prescribed based on infection severity

• Children: Dose calculated based on body weight, usually 25–50 mg/kg/day divided into 2–3 doses

• Take capsules with a full glass of water, preferably on an empty stomach for optimal absorption

• Complete the full course of therapy even if symptoms improve to prevent recurrence and development of resistance

Precautions and Warnings

• Use with caution in patients with history of penicillin allergy or hypersensitivity to cephalosporins

• Adjust dose in patients with renal impairment

• Not effective against viral infections; misuse may lead to antibiotic resistance

• Inform your physician if pregnant, breastfeeding, or taking other medications

Possible Side Effects

Sefril Capsule 500 mg is generally well tolerated. Side effects may include:

• Gastrointestinal disturbances: nausea, vomiting, diarrhea, abdominal discomfort

• Allergic reactions: rash, itching, urticaria

• Rare but serious reactions: anaphylaxis, neutropenia, liver enzyme changes

Most side effects are mild and reversible upon discontinuation or dose adjustment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from moisture and direct sunlight

• Keep out of reach of children

• Do not use capsules past their expiry date

Conclusion

Sefril Capsule 500 mg (Cephradine) is a powerful first-generation cephalosporin ideal for treating moderate to severe bacterial infections. Its broad-spectrum activity, oral convenience, and proven safety make it suitable for adults and children as prescribed by a physician. Proper use ensures effective bacterial eradication, symptom relief, and prevention of infection complications.