Synamet Plus Tablet 50 mg+12.5 mg+200 mg is a combination medicine used in the treatment of Parkinson’s disease. It contains Levodopa, Carbidopa, and Entacapone, which work together to improve movement control, reduce tremors, and manage “wearing-off” symptoms in patients with advanced Parkinson’s disease.

This triple combination helps maintain more stable dopamine levels in the brain, improving daily mobility and reducing motor fluctuations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Levodopa 50 mg
• Carbidopa 12.5 mg
• Entacapone 200 mg
• Dosage Form: Oral Tablet

Indications

Synamet Plus Tablet is indicated for:

• Parkinson’s disease (especially advanced stages)
• Motor fluctuations (“on-off” phenomenon)
• Wearing-off effect of Levodopa therapy
• Tremors, rigidity, and bradykinesia
• Dopamine deficiency-related movement disorders

How Synamet Plus Tablet Works

This combination works through three complementary mechanisms:

• Levodopa: Converts into dopamine in the brain, improving movement and coordination.
• Carbidopa: Prevents early breakdown of Levodopa in the body, increasing its availability in the brain and reducing side effects.
• Entacapone: Inhibits the COMT enzyme, prolonging the effect of Levodopa and helping maintain stable dopamine levels.

Together, they provide longer and smoother control of Parkinson’s symptoms.

Dosage and Administration

• Take exactly as prescribed by a physician.
• Usually taken with each Levodopa dose or as directed.
• Can be taken with or without food, but consistency is important.
• Do not stop suddenly without medical supervision.

Dosage is individualized based on symptom control and patient response.

Benefits of Synamet Plus Tablet

• Improves movement control and mobility
• Reduces tremors and muscle stiffness
• Helps manage “wearing-off” symptoms
• Provides longer-lasting effect of Levodopa
• Improves quality of life in advanced Parkinson’s disease

Possible Side Effects

Some patients may experience:

• Nausea or vomiting
• Dizziness or low blood pressure
• Involuntary movements (dyskinesia)
• Diarrhea (more common due to Entacapone)
• Sleep disturbances
• Orange discoloration of urine (harmless effect of Entacapone)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under neurological supervision
• Do not discontinue abruptly
• May cause drowsiness—avoid driving if affected
• Use cautiously in liver, heart, or kidney disease
• May interact with antidepressants and other CNS drugs
• Regular monitoring is recommended for long-term therapy

Storage Instructions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.