Telmisartan works by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle and adrenal tissue. Angiotensin II is a potent vasoconstrictor that also stimulates aldosterone secretion, leading to sodium and water retention. By blocking these effects, telmisartan causes vasodilation and reduces peripheral vascular resistance.
Hydrochlorothiazide acts on the distal convoluted tubule of the kidney, inhibiting sodium and chloride reabsorption. This increases the excretion of sodium and water, resulting in a reduction in plasma volume and blood pressure.
The combined action of these two agents produces an additive antihypertensive effect, providing better blood pressure control than either drug alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Telma Plus Tablet 40 mg + 12.5 mg is indicated for:

• Treatment of essential hypertension in adults

• Patients whose blood pressure is not adequately controlled with telmisartan or hydrochlorothiazide alone

• Patients requiring combination therapy for effective blood pressure management

Dosage and Administration

• Dosage should be individualized based on patient response

• The usual recommended dose is one tablet once daily

• Tablets may be taken with or without food

• Regular monitoring of blood pressure, electrolytes, and renal function is recommended

• Not intended for initial therapy unless clearly indicated

Contraindications

• Hypersensitivity to telmisartan, hydrochlorothiazide, sulfonamide-derived drugs, or any component of the formulation

• Pregnancy and lactation

• Severe renal impairment or anuria

• Severe hepatic impairment or biliary obstructive disorders

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Warnings and Precautions

• Hypotension may occur, especially in volume- or sodium-depleted patients

• Monitor serum electrolytes, particularly potassium, sodium, and magnesium

• Use with caution in patients with renal or hepatic impairment

• Avoid concomitant use with aliskiren in patients with diabetes

• Patients should be advised about adequate hydration

Side Effects

Commonly reported side effects may include:

• Dizziness or headache

• Hypotension

• Electrolyte imbalance

• Increased urination

• Fatigue

Most adverse effects are mild to moderate and resolve with continued therapy or dose adjustment.

Drug Interactions

• NSAIDs may reduce antihypertensive effect and increase the risk of renal impairment

• Potassium supplements or potassium-sparing diuretics may increase the risk of hyperkalemia

• Other antihypertensive agents may enhance blood pressure-lowering effects

Pregnancy and Lactation

• Telma Plus Tablet is contraindicated during pregnancy due to the risk of fetal harm

• Use during breastfeeding is not recommended

Storage Conditions

• Store below 30°C in a cool and dry place

• Protect from light and moisture

• Keep out of reach of children

Presentation

Telma Plus Tablet 40 mg + 12.5 mg is available in blister packs, ensuring convenient dosing and product stability.