Temonix Capsule 250 mg contains Temozolomide, an oral alkylating chemotherapy medicine used in the treatment of certain malignant brain tumors. It is primarily indicated for glioblastoma multiforme and anaplastic astrocytoma. Temozolomide works by damaging the DNA of cancer cells, leading to inhibition of tumor growth and cell death.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Temozolomide 250 mg

Mechanism of Action

Temozolomide is a prodrug that converts in the body into its active metabolite, MTIC (monomethyl triazeno imidazole carboxamide). MTIC causes methylation of DNA at the O6 and N7 positions of guanine, resulting in DNA damage. This prevents cancer cells from replicating and leads to their programmed cell death, particularly in rapidly dividing tumor cells.

Indications

Temonix Capsule 250 mg is indicated for:

• Glioblastoma multiforme (newly diagnosed and recurrent)
• Anaplastic astrocytoma (refractory or recurrent cases)
• Other high-grade brain tumors as determined by an oncologist

Dosage and Administration

• Dosage must be strictly prescribed by an oncologist based on body surface area and treatment protocol.
• Usually taken once daily in treatment cycles.
• Should be taken on an empty stomach or as directed by the physician.
• Swallow whole with water; do not open, crush, or chew the capsule.
• Anti-nausea medication may be given before dosing if required.

Benefits

• Effective oral chemotherapy for brain tumors
• Crosses the blood-brain barrier efficiently
• Can be used in combination with radiotherapy or other anticancer drugs
• Improves progression-free survival in eligible patients
• Convenient oral administration compared to injectable chemotherapy

Side Effects

Common side effects may include:

• Nausea and vomiting
• Fatigue
• Loss of appetite
• Headache
• Constipation or diarrhea

Serious side effects may include bone marrow suppression (low white blood cells, red blood cells, or platelets), increased risk of infections, bleeding tendencies, or liver function abnormalities. Immediate medical attention is required if severe symptoms occur.

Precautions and Warnings

• Must be used only under strict oncology supervision.
• Regular blood count monitoring is essential during therapy.
• Increased risk of infections due to immunosuppression.
• Not recommended during pregnancy due to potential fetal harm.
• Effective contraception is required during and after treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Temonix Capsule may interact with:

• Valproic acid (may increase risk of bone marrow suppression)
• Other chemotherapy or immunosuppressive agents
• Drugs affecting liver enzyme activity
• Certain antiviral or antibiotic medications

Always inform your healthcare provider about all medicines being used.

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.