Tofacinix Tablet 11 mg contains Tofacitinib, an oral Janus kinase (JAK) inhibitor used to treat several autoimmune and inflammatory conditions. It works by modulating the immune response and reducing inflammation, helping to control disease symptoms and improve physical function in affected patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Tofacinix Tablet is indicated for:

• Rheumatoid arthritis (moderate to severe)
• Psoriatic arthritis
• Ankylosing spondylitis (in selected cases)
• Ulcerative colitis (moderate to severe)
• Other autoimmune conditions as prescribed by a specialist

Mechanism of Action

Tofacitinib works by inhibiting Janus kinase (JAK) enzymes involved in cytokine signaling. This leads to:

• Reduced activation of immune cells
• Decreased production of inflammatory mediators
• Suppression of abnormal immune responses

As a result, inflammation, pain, and tissue damage are reduced.

Dosage and Administration

• The usual dose is 11 mg once daily (extended-release formulation), or as prescribed by a physician
• Can be taken with or without food
• Swallow the tablet whole with water
• Do not crush or chew the tablet
• Dose adjustments may be required based on clinical response and safety monitoring

Benefits

• Reduces joint pain, swelling, and stiffness
• Improves physical function and mobility
• Helps control chronic autoimmune inflammation
• Oral alternative to injectable biologic therapies
• Convenient once-daily dosing (for XR formulation)

Side Effects

Common side effects may include:

• Upper respiratory tract infections
• Headache
• Diarrhea
• Nausea
• Increased cholesterol levels

Serious side effects:

• Serious infections (bacterial, viral, or fungal)
• Blood clots (deep vein thrombosis, pulmonary embolism)
• Liver enzyme elevation
• Low blood cell counts
• Increased risk of malignancy in long-term use

Precautions and Warnings

• Increased risk of serious infections; screen for tuberculosis before use
• Not recommended in patients with active severe infections
• Use cautiously in patients with liver or kidney disease
• Regular monitoring of blood counts, liver function, and lipids is required
• Avoid live vaccines during treatment
• Not recommended during pregnancy unless clearly necessary

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Tofacinix Tablet may interact with:

• Strong immunosuppressants
• Azole antifungals
• Rifampicin
• Other biologic or DMARD therapies

Medical supervision is essential when used in combination therapy.

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.