Tofen 1 mg contains Ketotifen, a potent anti-allergic agent with a strong and long-lasting non-competitive histamine (H1) receptor blocking action. It works by inhibiting the release of allergic mediators such as histamine, leukotrienes, and prostaglandins from mast cells involved in type I allergic reactions.

Additionally, Ketotifen stabilizes mast cells and basophils, reduces eosinophil chemotaxis and degranulation, and inhibits platelet-activating factor (PAF). Through these mechanisms, Tofen 1 mg helps prevent bronchial hyperreactivity and reduces the frequency of asthmatic attacks.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage & Administration

• Adults: 1 mg twice daily with food. In severe cases, the dose may be increased to 2 mg twice daily as advised by a physician.

• Children above 2 years: 1 mg twice daily with food.

• Patients prone to sedation: Start with 0.5–1 mg at night for the first few days.

• Elderly: Same as adult dose or as directed by the physician.

Drug Interactions

• Concomitant use with oral antidiabetic agents may cause a reversible reduction in platelet count and should be avoided.

• Ketotifen may potentiate the effects of CNS depressants such as alcohol, sedatives, hypnotics, and other antihistamines.

Contraindications

• Use with oral antidiabetic drugs is contraindicated due to the risk of reversible thrombocytopenia.

Side Effects

• Drowsiness

• Dry mouth

• Mild dizziness

These effects are usually transient and subside after a few days of continued therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy & Lactation

Although no teratogenic effects have been documented, the use of Ketotifen during pregnancy and lactation is not recommended unless clearly necessary.

Precautions & Warnings

• Previous asthma treatments should be continued for at least two weeks after starting Tofen 1 mg to avoid asthma exacerbation.

• Special caution is required in patients dependent on systemic corticosteroids or ACTH due to possible adrenocortical insufficiency.

• Patients should avoid driving or operating machinery during the initial days of treatment until individual response is known.

• Alcohol consumption should be avoided as Ketotifen may enhance sedative effects.

• In case of intercurrent infection, appropriate antimicrobial therapy should be added.

Overdose Effects

Symptoms:
Drowsiness, confusion, dyspnea, bradycardia or tachycardia, disorientation, convulsions, severe hypotension, and reversible coma.

Management:
Supportive and symptomatic treatment is recommended.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.