Trexall Injection 50 mg/2 ml contains Methotrexate, an antimetabolite and immunosuppressant medicine used in the treatment of certain cancers, autoimmune diseases, and severe inflammatory conditions. It works by inhibiting cell growth and reducing abnormal immune system activity.

Methotrexate is widely used in oncology and rheumatology due to its effectiveness in controlling rapid cell division and excessive immune responses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 2 ml vial contains:

• Methotrexate 50 mg

Available as a sterile solution for intravenous, intramuscular, or subcutaneous administration as directed by a healthcare professional.

Indications

Trexall Injection is indicated for:

• Acute lymphoblastic leukemia (ALL)
• Non-Hodgkin lymphoma
• Osteosarcoma
• Breast cancer (in combination therapy)
• Rheumatoid arthritis (severe cases)
• Psoriasis (severe, refractory cases)
• Other autoimmune and inflammatory disorders as prescribed

Mechanism of Action

Methotrexate works by inhibiting dihydrofolate reductase (DHFR), an enzyme required for DNA synthesis and cell replication. This leads to reduced proliferation of rapidly dividing cells, including cancer cells and immune cells involved in inflammation.

Its immunosuppressive and anti-inflammatory effects make it useful in both cancer therapy and autoimmune disease management.

Dosage and Administration

Trexall Injection must be administered only under strict medical supervision.

General guidelines:

• Route: Intravenous, intramuscular, or subcutaneous
• Dose depends on condition, body surface area, and treatment protocol
• Often given in cycles for cancer therapy
• Low-dose regimens used for autoimmune diseases
• Regular monitoring is essential

Folic acid supplementation may be prescribed to reduce side effects in non-oncologic use.

Benefits of Trexall Injection

• Effective in treating various cancers
• Reduces abnormal immune activity in autoimmune diseases
• Helps control severe rheumatoid arthritis and psoriasis
• Slows disease progression
• Well-established and widely used chemotherapy agent

Possible Side Effects

Methotrexate may cause:

• Nausea and vomiting
• Mouth ulcers
• Fatigue
• Hair loss
• Reduced blood cell counts
• Liver function abnormalities

Serious side effects include:

• Bone marrow suppression
• Liver toxicity
• Lung inflammation (methotrexate pneumonitis)
• Severe infections

Immediate medical attention is required if serious symptoms occur.

Precautions and Warnings

• Requires regular blood count and liver function monitoring
• Not safe during pregnancy (can cause birth defects)
• Avoid alcohol due to increased liver toxicity risk
• Use caution in kidney or liver disease
• Do not self-administer without medical supervision
• Folic acid supplementation may be required in low-dose therapy

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store below 25°C
• Protect from light
• Do not freeze
• Keep out of reach of children
• Use only under healthcare supervision

Conclusion

Trexall Injection 50 mg/2 ml (Methotrexate) is a powerful anticancer and immunosuppressive medicine used in the treatment of cancers, rheumatoid arthritis, and severe psoriasis. It works by inhibiting cell division and reducing immune overactivity. Due to its potent effects and potential toxicity, it must be used with careful monitoring under specialist supervision.