Trexonate Injection 50 mg/2 ml contains Methotrexate, a potent antimetabolite and disease-modifying antirheumatic drug (DMARD). It is used in the treatment of certain cancers and autoimmune diseases by inhibiting abnormal cell growth and suppressing overactive immune responses. This injectable form is used when rapid or more controlled therapeutic action is required under strict medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Trexonate Injection is indicated for:

• Rheumatoid arthritis (severe or resistant cases)
• Psoriasis and psoriatic arthritis
• Certain malignancies (as part of chemotherapy regimens)
• Juvenile idiopathic arthritis
• Other autoimmune or inflammatory conditions as prescribed by a specialist

Mechanism of Action

Methotrexate inhibits the enzyme dihydrofolate reductase (DHFR), which is essential for DNA synthesis. This leads to:

• Inhibition of rapidly dividing cells
• Suppression of abnormal immune system activity
• Reduction of inflammatory cytokine production

At low doses, it acts mainly as an immunosuppressant; at higher doses, it has cytotoxic effects used in oncology.

Dosage and Administration

• Administered by intramuscular (IM), intravenous (IV), or subcutaneous (SC) injection under medical supervision
• Dosage is strictly individualized based on condition and patient response
• In many autoimmune conditions, it is given once weekly, not daily
• Must be administered by trained healthcare professionals
• Regular laboratory monitoring is mandatory during treatment

Benefits

• Effective in controlling severe rheumatoid arthritis
• Reduces inflammation and joint damage progression
• Helps manage severe psoriasis
• Useful in selected cancer treatment protocols
• Provides reliable systemic delivery for faster therapeutic effect

Side Effects

Common side effects may include:

• Nausea and vomiting
• Fatigue
• Mouth ulcers
• Loss of appetite
• Temporary hair thinning

Serious side effects:

• Bone marrow suppression (low blood cell counts)
• Liver toxicity
• Lung inflammation (methotrexate pneumonitis)
• Increased risk of infections

Precautions and Warnings

• Strictly avoid daily administration unless directed by a physician
• Contraindicated in pregnancy and breastfeeding
• Regular monitoring of blood counts, liver, and kidney function is essential
• Avoid alcohol due to increased risk of liver damage
• Use cautiously in patients with liver, kidney, or blood disorders
• Avoid live vaccines during treatment
• Use only under specialist supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Trexonate Injection may interact with:

• NSAIDs (increased toxicity risk)
• Certain antibiotics (penicillins, sulfonamides)
• Other immunosuppressants
• Proton pump inhibitors

Close medical supervision is required when used with other medications.

Storage

• Store below 25°C in a dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.