Trexonate Tablet 2.5 mg contains Methotrexate, a disease-modifying antirheumatic drug (DMARD) and antimetabolite used in the treatment of autoimmune diseases and certain types of cancer. It works by inhibiting abnormal cell growth and reducing immune system activity, helping control inflammation and disease progression.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Trexonate Tablet is indicated for:

• Rheumatoid arthritis (moderate to severe)
• Psoriasis and psoriatic arthritis
• Certain types of cancer (as per oncology protocols)
• Juvenile idiopathic arthritis
• Other autoimmune disorders as prescribed by a specialist

Mechanism of Action

Methotrexate inhibits the enzyme dihydrofolate reductase (DHFR), which is essential for DNA synthesis. This leads to:

• Reduced rapid cell division
• Suppression of overactive immune responses
• Decreased inflammation in autoimmune conditions

At low doses, it acts mainly as an immunomodulator; at higher doses, it has cytotoxic effects on cancer cells.

Dosage and Administration

• Dosage is strictly individualized based on disease condition
• Commonly administered once weekly, not daily, under medical supervision
• Should be taken exactly as prescribed by a physician
• Folic acid supplementation may be recommended to reduce side effects
• Regular monitoring of blood tests is essential during therapy

Benefits

• Reduces joint pain, swelling, and stiffness in rheumatoid arthritis
• Slows disease progression in autoimmune disorders
• Improves skin lesions in psoriasis
• Effective in selected cancer treatment protocols
• Long-term disease control with proper monitoring

Side Effects

Common side effects may include:

• Nausea and vomiting
• Mouth ulcers
• Fatigue
• Loss of appetite
• Hair thinning

Serious side effects:

• Liver toxicity
• Bone marrow suppression (low blood cells)
• Lung inflammation (methotrexate pneumonitis)
• Increased infection risk

Precautions and Warnings

• Strictly avoid daily use unless specifically directed
• Not recommended during pregnancy or breastfeeding
• Regular monitoring of liver function, kidney function, and blood counts is required
• Avoid alcohol due to increased risk of liver damage
• Use caution in patients with liver, kidney, or blood disorders
• Avoid live vaccines during treatment

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Trexonate Tablet may interact with:

• NSAIDs (may increase toxicity)
• Certain antibiotics (e.g., penicillins, sulfonamides)
• Other immunosuppressants
• Proton pump inhibitors (may increase methotrexate levels)

Medical supervision is essential to prevent complications.

Storage

• Store below 25°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.