Tricalm Tablet 5 mg contains Trihexyphenidyl Hydrochloride, a centrally acting anticholinergic agent used to manage Parkinson’s disease and drug-induced extrapyramidal symptoms (EPS). By restoring the balance between dopamine and acetylcholine in the brain, it effectively reduces tremors, muscle stiffness, and involuntary movements, improving overall motor function.

This higher-strength formulation is suitable for patients requiring more potent symptom control after titration from lower doses, providing better relief from severe Parkinsonian or drug-induced motor symptoms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Tricalm Tablet is indicated for:

• Parkinson’s disease: to control tremors, rigidity, bradykinesia, and postural instability
• Drug-induced extrapyramidal symptoms (EPS), including dystonia, akathisia, and involuntary movements caused by antipsychotic medications
• Adjunct therapy in patients not adequately controlled with lower doses or other Parkinsonism medications
• Improvement of motor coordination and daily functioning

Mechanism of Action

Trihexyphenidyl works as an anticholinergic agent:

• Blocks muscarinic acetylcholine receptors in the central nervous system
• Restores the dopamine-acetylcholine balance in the basal ganglia
• Reduces tremors, muscle rigidity, and involuntary movements
• Improves overall motor control and coordination

By targeting neurotransmitter imbalance, Tricalm helps alleviate key symptoms of Parkinsonism and EPS.

Dosage and Administration

• Recommended starting dose: 2–5 mg orally, 2–3 times daily, adjusted based on response and tolerability
• Tablets can be taken with or without food
• Dose increases should be gradual to minimize side effects
• Elderly patients should start with the lowest effective dose
• Adjustments may be needed in cases of renal or hepatic impairment

Benefits

• Controls tremors, rigidity, and involuntary movements
• Enhances mobility, balance, and daily activity performance
• Provides effective management of drug-induced movement disorders
• Simple oral therapy for consistent symptom relief
• Helps improve quality of life for patients with Parkinsonism or EPS

Side Effects

Common side effects may include:

• Dry mouth
• Blurred vision
• Constipation
• Drowsiness or dizziness
• Nausea

Serious but rare side effects:

• Confusion, hallucinations, or cognitive impairment, particularly in elderly patients
• Urinary retention or difficulty urinating
• Rapid heartbeat (tachycardia)
• Severe allergic reactions

Seek immediate medical attention if severe confusion, urinary problems, or cardiovascular issues occur.

Precautions and Warnings

• Use with caution in elderly patients due to increased risk of cognitive impairment and hallucinations
• Contraindicated in patients with glaucoma, severe constipation, urinary obstruction, or cardiac arrhythmias
• May impair the ability to drive or operate machinery
• Pregnancy and breastfeeding: use only under medical supervision
• Monitor for worsening Parkinsonian symptoms or cognitive changes during therapy

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Trihexyphenidyl may interact with:

• Other anticholinergic medications (additive effects)
• CNS depressants (enhanced sedation)
• Antihypertensives (possible blood pressure effects)
• Certain antipsychotics (may require dose adjustment)

Always inform your healthcare provider of all medications and supplements being taken before starting therapy.

Storage

• Store below 25°C in a dry, cool place
• Protect from light and moisture
• Keep out of reach of children
• Do not use after the expiration date.