Trihale Inhalation Capsule 25 mcg + 100 mcg + 62.5 mcg is a triple-combination inhalation therapy designed for the long-term management of chronic obstructive pulmonary disease (COPD) and severe asthma. It contains:

• Vilanterol Trifenatate 25 mcg – a long-acting β2-adrenergic agonist (LABA)

• Fluticasone Furoate 100 mcg – an inhaled corticosteroid (ICS)

• Umeclidinium Bromide 62.5 mcg – a long-acting muscarinic antagonist (LAMA)

This combination targets multiple mechanisms in the airways to improve breathing, reduce inflammation, and prevent disease exacerbations. Delivered via a dry powder inhaler (DPI), it ensures that the medication reaches the lungs directly for maximum efficacy and minimal systemic side effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Trihale Inhalation Capsule 25 mcg + 100 mcg + 62.5 mcg is indicated for:

• Chronic Obstructive Pulmonary Disease (COPD): Long-term maintenance therapy to improve lung function and reduce flare-ups

• Severe asthma: For patients inadequately controlled with dual therapy (ICS + LABA)

• Prevention of exacerbations: Reduces frequency and severity of hospitalizations due to respiratory flare-ups

• Maintenance therapy: Suitable for adults requiring daily inhalation to manage symptoms effectively

This formulation is not for acute symptom relief; patients should use a short-acting bronchodilator for sudden breathing difficulties.

Mechanism of Action

Trihale combines three active agents to provide comprehensive airway management:

1. Vilanterol Trifenatate (LABA): Stimulates β2-adrenergic receptors, causing bronchial smooth muscle relaxation and improved airflow

2. Fluticasone Furoate (ICS): Reduces airway inflammation, suppressing immune responses and preventing airway swelling

3. Umeclidinium Bromide (LAMA): Blocks muscarinic receptors in the lungs, reducing bronchoconstriction and mucus production

This triple action ensures enhanced bronchodilation, reduced inflammation, and better overall respiratory function with once-daily dosing.

Dosage and Administration

• Recommended dose: 1 inhalation once daily via a compatible dry powder inhaler

• Instructions: Insert the capsule into the inhaler device, inhale deeply, and hold your breath for a few seconds to ensure optimal lung deposition

• Do not swallow the capsule; it is intended for inhalation only

• Consistency is essential: Daily use at the same time helps maintain 24-hour symptom control and reduces the risk of exacerbations

• Acute symptoms: Keep a short-acting bronchodilator available for rescue use

Precautions and Warnings

• Not for acute attacks: Use only as maintenance therapy; rescue inhalers should be available

• Cardiovascular conditions: Monitor patients with hypertension, arrhythmias, or other heart diseases, as LABA may affect heart rate

• Glaucoma and urinary retention: LAMA component may worsen these conditions

• Pregnancy and breastfeeding: Use only if benefits outweigh risks and under medical supervision

• Allergic reactions: Avoid in patients hypersensitive to any component of the medication

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Trihale Inhalation Capsule is generally well tolerated. Common side effects may include:

• Headache, throat irritation, or cough

• Dry mouth (due to LAMA component)

• Mild tremors or palpitations

• Rare: hypersensitivity reactions, including rash, swelling, or difficulty breathing

Most side effects are mild and transient. Report severe or persistent symptoms to a healthcare professional.

Storage

Store capsules in a cool, dry place below 30°C, protected from moisture and light. Keep out of reach of children.

Trihale Inhalation Capsule 25 mcg + 100 mcg + 62.5 mcg offers comprehensive, once-daily management of COPD and severe asthma, improving lung function, controlling inflammation, and reducing exacerbations for better respiratory health.