Cefixime is a third-generation semisynthetic cephalosporin antibiotic for oral use. It exerts its bactericidal action by inhibiting bacterial cell wall synthesis. Due to its high resistance to beta-lactamase enzymes, it remains effective against many beta-lactamase-producing organisms. Oral absorption ranges from approximately 40% to 50% and is not significantly affected by food intake.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Adults and children over 12 years:
  200–400 mg daily, given as a single dose or in two divided doses
  For uncomplicated gonococcal infections: a single oral dose of 400 mg

• Children (6 months or older):
  8 mg/kg/day given as a single dose or in two divided doses
  General daily dosing guide:

  • 6–12 months: 75 mg

  • 1–4 years: 100 mg

  • 5–10 years: 200 mg

  • 11–12 years: 300 mg

• Typhoid fever:
  10 mg/kg/day for 14 days in children

• Elderly:
  Same dose as adults; renal function should be assessed

• Renal impairment:
  Dose adjustment required in severe renal impairment (maximum 200 mg daily if creatinine clearance <20 ml/min)

The usual course of treatment is 7 days and may be extended up to 14 days depending on infection severity.

Drug Interactions

Prolongation of prothrombin time has been reported in some patients. Caution is advised when administered concomitantly with anticoagulant therapy.

Contraindications

Triocim 200 mg is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Triocim 200 mg is generally well tolerated. Most adverse effects are mild and self-limiting.

• Gastrointestinal: Diarrhea, nausea, abdominal pain, dyspepsia, vomiting, flatulence; rare cases of pseudomembranous colitis

• Central Nervous System: Headache, dizziness

• Hypersensitivity: Rash, pruritus, urticaria, drug fever, arthralgia

• Hematological: Thrombocytopenia, leukopenia, eosinophilia (rare and reversible)

• Others: Transient changes in liver or renal function tests, genital pruritus, vaginitis

Pregnancy and Lactation

There are no adequate and well-controlled studies in pregnant women. Triocim 200 mg should be used during pregnancy only if clearly needed. It is not known whether Cefixime is excreted in human milk; therefore, caution is advised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients with a history of hypersensitivity to penicillins due to possible cross-reactivity

• Discontinue immediately if allergic reactions occur

• Use cautiously in patients with severe renal impairment

• Prolonged use may result in overgrowth of non-susceptible organisms, including Clostridium difficile

Overdose

There is no specific antidote for Cefixime overdose. Gastric lavage may be considered. Cefixime is not significantly removed by hemodialysis or peritoneal dialysis.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.