Trum 3 Injection 1 gm/vial contains Ceftazidime Pentahydrate 1 gram, a third-generation cephalosporin antibiotic with potent broad-spectrum activity against Gram-negative bacteria, including Pseudomonas aeruginosa, as well as some Gram-positive organisms. It is specifically formulated for the treatment of severe and complicated bacterial infections that require hospital-based care.

Trum 3 Injection 1 gm/vial is widely used in managing serious infections such as respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, and bone or joint infections. Its bactericidal action and resistance to many bacterial β-lactamases make it a reliable choice for treating resistant bacterial strains, including hospital-acquired infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Ceftazidime Pentahydrate 1 gm per vial

Mechanism of Action

Ceftazidime, the active ingredient in Trum 3 Injection, acts as a bactericidal antibiotic by:

1. Inhibiting bacterial cell wall synthesis – Binds to penicillin-binding proteins (PBPs) in bacteria, disrupting the cross-linking of peptidoglycan layers in the cell wall.

2. Bacterial lysis and death – Weakening the cell wall leads to osmotic instability, resulting in bacterial cell rupture.

3. Broad-spectrum activity – Effective against Gram-negative bacteria, including Pseudomonas aeruginosa, and some Gram-positive strains.

4. Resistance to β-lactamases – Maintains activity against many bacteria that produce β-lactamase enzymes, enhancing its therapeutic efficacy.

This combination of actions allows Trum 3 to rapidly control infection and prevent progression of severe bacterial diseases.

Indications

Trum 3 Injection 1 gm/vial is indicated for:

• Severe respiratory tract infections – pneumonia, bronchitis, and hospital-acquired lung infections

• Urinary tract infections – complicated or severe infections

• Skin and soft tissue infections – cellulitis, abscesses, and post-operative wound infections

• Intra-abdominal infections – peritonitis and secondary infections

• Bone and joint infections – osteomyelitis and septic arthritis

• Septicemia and bloodstream infections – including infections caused by resistant organisms

It is suitable for adult and pediatric patients requiring intensive treatment under physician supervision.

Dosage and Administration

• Administer intravenously (IV) or intramuscularly (IM) after reconstitution using sterile technique.

• Adults: Typically 500 mg to 2 g every 8–12 hours depending on infection severity.

• Pediatric patients: Dose calculated according to body weight and clinical condition.

• Adjust dosage in patients with renal impairment to prevent toxicity.

• Duration of therapy depends on infection type, severity, and response to treatment.

Benefits

• Rapid and effective bactericidal activity against a broad spectrum of bacteria

• Effective against resistant Gram-negative bacteria, including Pseudomonas

• Suitable for severe, complicated, or hospital-acquired infections

• Versatile administration via IV or IM routes

• Can be used as monotherapy or in combination therapy for serious infections

Precautions

• Caution in patients with penicillin or cephalosporin allergy

• Monitor renal function during prolonged therapy; adjust doses in renal impairment

• Avoid prolonged use to reduce risk of antibiotic resistance or secondary infections

• Observe for superinfections, including Clostridium difficile-associated diarrhea

• Use in pregnancy and lactation only if clearly needed and under medical supervision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects:

• Pain, redness, or swelling at injection site

• Gastrointestinal disturbances: nausea, vomiting, diarrhea

• Mild headache or dizziness

Serious but rare side effects:

• Allergic reactions: rash, itching, or anaphylaxis

• Severe diarrhea or colitis due to Clostridium difficile

• Blood disorders: neutropenia, thrombocytopenia, or eosinophilia

Storage

• Store below 25°C in a cool, dry place

• Protect from light and moisture

• Keep the vial tightly closed until use

• Keep out of reach of children

Trum 3 Injection 1 gm/vial is a potent cephalosporin antibiotic for severe and complicated bacterial infections, providing broad-spectrum coverage and rapid bactericidal action under careful medical supervision.