Intafenac 50 mg is a non-steroidal anti-inflammatory drug (NSAID) widely used for pain relief, inflammation control, and management of rheumatic conditions. Its main indications include:

1. Rheumatology:

   • Inflammatory and degenerative rheumatism

   • Chronic involutive and polyarthritis

   • Ankylosing spondylarthritis

   • Osteoarthritis and spondylarthroses

   • Acute gout attacks

   • Peri-articular rheumatic disorders

2. Surgery and Traumatology:

   • Sprains, bruises, dislocations, fractures

   • Soft tissue injuries and post-surgical pain

3. Obstetrics & Gynecology:

   • Primary dysmenorrhea

   • Episiotomy pain

   • Infections and inflammation such as adnexitis, endometritis, parametritis, salpingitis, mastitis

4. Otorhinolaryngology:

   • Pre-operative medication to reduce pain, inflammation, and swelling

5. Dentistry:

   • Post-operative or post-traumatic pain, swelling, and inflammation

6. Other Indications:

   • Pain and inflammation following urogenital surgeries

   • Renal or biliary colic management

     রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

• Drugs for Osteoarthritis

• Drugs used for Rheumatoid Arthritis

Pharmacology / Mode of Action

Intafenac 50 mg contains diclofenac, a potent NSAID with anti-inflammatory, analgesic, antipyretic, and anti-rheumatic properties.

Mechanism of Action:

• Inhibits prostaglandin biosynthesis, which is responsible for pain, inflammation, and fever.

• Rapid absorption from the gastrointestinal tract when taken with or after meals.

• Peak plasma concentration occurs within 2 hours of oral administration.

• Highly protein-bound (99.7%) and metabolized in the liver via first-pass metabolism.

• Also exhibits a mild uricosuric effect, beneficial in acute gout attacks.

Dosage & Administration

Oral Tablet / Sustained Release / Dispersible Tablet:

• Adults: 75–150 mg daily in divided doses

• Sustained release: 1 tablet daily, may supplement with conventional tablets up to 150 mg

• Dispersible tablet: 2–3 tablets daily; maximum 150 mg

Suppository:

• Adults: 50 mg 2–3 times daily, max 150 mg

Injection:

• Adults: 1 ampoule intramuscularly daily; in severe cases, 2 ampoules daily

Gel (Topical):

• Apply 2–4 g to the affected area 3–4 times daily

Children:

• Only recommended for juvenile rheumatoid arthritis

• Dose: 1–3 mg/kg/day in divided doses

Elderly:

• Use the lowest effective dose due to increased sensitivity

Drug Interactions

• Diuretics: May reduce diuretic effectiveness

• Potassium-sparing diuretics: Risk of hyperkalemia

• Digoxin, Methotrexate, Cyclosporine, Lithium: Monitor for increased toxicity

• Other NSAIDs or glucocorticoids: Increased risk of gastrointestinal side effects

Contraindications

• Hypersensitivity to diclofenac or NSAIDs

• Peptic ulcer disease or gastrointestinal bleeding

• Asthma triggered by aspirin or NSAIDs

• Gel should not be applied under occlusive dressings

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

• Gastrointestinal: Epigastric pain, nausea, diarrhea

• Neurological: Dizziness, headache

• Dermatologic: Rash, eczema, local irritation (gel)

• Others: Peripheral edema, mild transient effects

Pregnancy & Lactation

• Avoid unless benefits outweigh risks

• Not recommended in the first trimester

• Minimal diclofenac may pass into breast milk; effects on infant are generally insignificant

Precautions & Warnings

• Monitor for peptic ulceration or GI bleeding, especially in elderly

• Avoid contact of gel with eyes or mucous membranes

• Wash hands after topical application

Storage

• Store in a cool, dry place below 30°C, protected from light

• Keep out of reach of children