Trum 3 Injection 500 mg/vial contains Ceftazidime Pentahydrate 500 mg, a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram-negative bacteria, including Pseudomonas aeruginosa, and select Gram-positive organisms. It is commonly used in the treatment of serious and complicated bacterial infections, particularly in hospital settings where resistant infections are prevalent.

Trum 3 Injection 500 mg is effective for managing infections of the respiratory tract, urinary tract, skin and soft tissues, intra-abdominal regions, bones, joints, and the bloodstream. Its potent bactericidal action and stability against many bacterial β-lactamases make it a reliable choice for severe infections that require rapid therapeutic intervention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Ceftazidime Pentahydrate 500 mg per vial

Mechanism of Action

Ceftazidime, the active ingredient in Trum 3 Injection, is a β-lactam antibiotic that exerts its effect by:

1. Inhibiting bacterial cell wall synthesis – Binds to penicillin-binding proteins (PBPs), preventing cross-linking of peptidoglycan layers, essential for cell wall integrity.

2. Bactericidal activity – Weakening the bacterial cell wall leads to cell lysis and death, controlling the infection.

3. Broad-spectrum coverage – Effective against Gram-negative organisms, including Pseudomonas, and some Gram-positive bacteria, making it versatile for mixed infections.

4. Resistance stability – Resistant to many bacterial β-lactamases, which allows treatment of infections caused by certain resistant bacterial strains.

These mechanisms ensure rapid bacterial clearance, reducing the risk of complications in severe infections.

Indications

Trum 3 Injection 500 mg/vial is indicated for:

• Respiratory tract infections – pneumonia, bronchitis, and severe lung infections

• Urinary tract infections – complicated or severe infections

• Skin and soft tissue infections – cellulitis, abscesses, and post-surgical wound infections

• Intra-abdominal infections – peritonitis and secondary infections

• Bone and joint infections – osteomyelitis and septic arthritis

• Septicemia and bloodstream infections – particularly in hospitalized or immunocompromised patients

It is suitable for adult and pediatric patients under careful medical supervision.

Dosage and Administration

• Administer intravenously (IV) or intramuscularly (IM) after proper reconstitution.

• Adults: Typically 500 mg to 2 g every 8 to 12 hours depending on infection severity.

• Pediatric patients: Dosage based on body weight and clinical condition.

• Reconstitution must be done under aseptic conditions.

• Adjust dose in patients with renal impairment to prevent toxicity.

• Duration of therapy is determined by the type and severity of infection and response to treatment.

Benefits

• Rapid and effective bactericidal activity against a broad range of bacteria

• Particularly effective against resistant Gram-negative infections, including Pseudomonas

• Versatile use in severe, hospital-acquired, or complicated infections

• Can be administered IV or IM for optimal delivery

• Supports both monotherapy and combination therapy in critical infections

Precautions

• Use cautiously in patients with a history of hypersensitivity to penicillins or cephalosporins.

• Monitor renal function during prolonged therapy; adjust dosage in renal impairment.

• Observe for signs of superinfection or Clostridium difficile-associated diarrhea.

• Pregnancy and lactation: Use only if clearly indicated by a physician.

• Avoid unnecessary prolonged use to reduce the risk of antibiotic resistance.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects:

• Injection site reactions: pain, redness, or swelling

• Gastrointestinal discomfort: nausea, vomiting, diarrhea

• Headache or mild dizziness

Serious but rare side effects:

• Severe allergic reactions: rash, itching, anaphylaxis

• Clostridium difficile-associated colitis

• Blood disorders: neutropenia, thrombocytopenia, or eosinophilia

Storage

• Store below 25°C in a cool, dry place

• Protect from light and moisture

• Keep vial tightly closed until use

• Keep out of reach of children

Trum 3 Injection 500 mg/vial is a potent cephalosporin antibiotic, providing broad-spectrum coverage and rapid bactericidal action for serious bacterial infections under careful medical supervision.