Turbocef 1.5 gm/vial is a parenteral broad-spectrum antibiotic containing Cefuroxime, a second-generation cephalosporin. It is widely used for the treatment of a variety of mild to severe bacterial infections caused by susceptible organisms, including β-lactamase–producing strains. Its strong bactericidal action and good stability against bacterial β-lactamase make it an effective choice in both community-acquired and hospital-based infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Second Generation Cephalosporin Antibiotic

Indications

Turbocef 1.5 gm/vial is indicated for the treatment of infections caused by sensitive bacteria, including:

• Upper respiratory tract infections

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes

• Ear, nose, and sinus infections

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (including β-lactamase–producing strains)

  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae

• Lower respiratory tract infections

  • Community-acquired pneumonia

  • Acute bacterial exacerbation of chronic bronchitis

  • Secondary bacterial infections of acute bronchitis

• Skin and soft tissue infections

  • Caused by Staphylococcus aureus or Streptococcus pyogenes

• Urinary tract infections

  • Caused by E. coli or Klebsiella pneumoniae

• Bone and joint infections

  • Caused by Staphylococcus aureus

• Sexually transmitted infections

  • Gonorrhoea caused by penicillinase-producing and non-producing strains of Neisseria gonorrhoeae

• Other infections

  • Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

  • Surgical prophylaxis

  • Meningitis and severe systemic infections (as clinically indicated)

Pharmacology

Cefuroxime is a well-established antibacterial agent with broad-spectrum bactericidal activity. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Cefuroxime demonstrates excellent resistance to β-lactamase enzymes, making it effective against many ampicillin- and amoxicillin-resistant organisms.

Dosage and Administration

Adults (Parenteral):

• Standard dose: 750 mg IM or IV three times daily

• Severe infections: Up to 1.5 gm IV three times daily (may be increased to four times daily if required)

• Meningitis: 3 gm IV three times daily

• Gonorrhoea: 1.5 gm IM as a single dose

• Bone and joint infections: 1.5 gm IV four times daily

Paediatric Patients:

• Children (above 3 months): 30–100 mg/kg/day in 3–4 divided doses

• Neonates: 30–100 mg/kg/day in 2–3 divided doses

Surgical Prophylaxis:

• 1.5 gm IV at induction of anaesthesia, followed by additional doses if required

Dosage and duration depend on the type and severity of infection and the patient’s clinical condition.

Reconstitution

• 750 mg IM: Add 3 ml Water for Injection

• 750 mg IV: Add 8 ml Water for Injection

• 1.5 gm IV: Add 16 ml Water for Injection

Shake gently until fully dispersed. Administer IV injections slowly over 3–5 minutes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Turbocef is contraindicated in patients with known hypersensitivity to cephalosporins.

Side Effects

Adverse effects are generally mild and transient and may include:

• Gastrointestinal disturbances

• Skin rashes

• Overgrowth of non-susceptible organisms with prolonged use

Drug Interactions

No clinically significant drug interactions have been reported.

Use in Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. Cefuroxime is excreted in breast milk; caution is advised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients receiving potent diuretics

• Caution in patients with a history of colitis

• Cross-sensitivity may occur in penicillin-allergic patients, though it is uncommon

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.