Turbocef 250 mg is indicated for the treatment of infections caused by susceptible organisms, including:

• Upper respiratory tract infections

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non β-lactamase producing strains)

• Ear infections

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (β-lactamase producing strains), or Streptococcus pyogenes

• Lower respiratory tract infections

  • Community-acquired pneumonia

  • Acute bacterial exacerbation of chronic bronchitis

  • Secondary bacterial infections of acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae, or Haemophilus parainfluenzae

• Skin and soft tissue infections

  • Infections caused by Staphylococcus aureus (including β-lactamase producing strains) or Streptococcus pyogenes

• Urinary tract infections

  • Caused by Escherichia coli or Klebsiella pneumoniae

• Bone and joint infections

  • Caused by Staphylococcus aureus

• Sexually transmitted infections

  • Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae

• Other infections

  • Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

  • Multidrug-resistant typhoid fever

    রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pharmacology

Cefuroxime is a well-established antibacterial agent that works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is highly stable against bacterial β-lactamases, making it effective against many ampicillin- and amoxicillin-resistant organisms.

Dosage and Administration

Oral (Tablet or Suspension)

Adolescents and Adults (≥13 years):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days

• Acute maxillary sinusitis: 250 mg twice daily for 10 days

• Chronic bronchitis exacerbation: 250–500 mg twice daily for 10 days

• Acute bronchitis (secondary bacterial infection): 250–500 mg twice daily for 5–10 days

• Uncomplicated skin infections: 250–500 mg twice daily for 10 days

• Uncomplicated UTI: 250 mg twice daily for 7–10 days

• Gonorrhoea: 1000 mg as a single dose

• Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days

• MDR typhoid fever: 500 mg twice daily for 10–14 days

• Early Lyme disease: 500 mg twice daily for 20 days

Paediatric Patients (3 months–12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses

• Acute otitis media: 30 mg/kg/day in two divided doses

• Acute sinusitis and impetigo: 30 mg/kg/day in two divided doses

Dosage should be adjusted according to the severity of infection and clinical response.

Contraindications

Turbocef 250 mg is contraindicated in patients with known hypersensitivity to cefuroxime or other cephalosporin antibiotics.

Side Effects

Cefuroxime is generally well tolerated. Possible side effects include:

• Gastrointestinal disturbances

• Skin rashes

• Overgrowth of non-susceptible organisms such as Candida with prolonged use

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

No clinically significant or potentially hazardous drug interactions have been reported.

Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only when clearly needed. Cefuroxime is excreted in breast milk; therefore, caution is advised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients with a history of colitis

• Caution is advised when used with potent diuretics

• Cross-reactivity may occur in patients with penicillin allergy

Storage Conditions

Store in a cool and dry place below 30°C. Protect from light and moisture. Keep out of reach of children.