Varizil Injection 500 mg/100 ml contains Metronidazole 500 mg in a sterile intravenous solution. It is a broad-spectrum antibacterial and antiprotozoal agent used for the treatment of serious infections caused by anaerobic bacteria and protozoa.

This IV formulation is especially valuable in hospital settings for patients who cannot take oral medications due to vomiting, gastrointestinal disorders, or critical illness. Varizil Injection 500 mg/100 ml is used in intra-abdominal infections, pelvic infections, severe skin and soft tissue infections, sepsis, and complicated protozoal infections, providing rapid and effective antimicrobial action.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Metronidazole 500 mg per 100 ml intravenous solution

Mechanism of Action

Metronidazole, the active ingredient in Varizil Injection, works through:

1. DNA disruption – Metronidazole enters anaerobic bacterial or protozoal cells and is reduced to active metabolites that bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis.

2. Bactericidal and protozoacidal activity – Leads to rapid death of susceptible anaerobic bacteria and protozoa.

3. Selective anaerobic activity – Effective against low-oxygen pathogens, commonly responsible for intra-abdominal, pelvic, and soft tissue infections.

4. Rapid onset – Ensures quick reduction of infection-related symptoms, improving patient outcomes in acute and severe infections.

This mechanism makes Varizil Injection a reliable choice for serious infections requiring intravenous therapy.

Indications

Varizil Injection 500 mg/100 ml is indicated for:

• Anaerobic bacterial infections – Including intra-abdominal abscesses, peritonitis, and soft tissue infections

• Gynecological infections – Pelvic inflammatory disease and post-surgical infections

• Severe gastrointestinal infections – Amoebiasis, giardiasis, and other protozoal infections

• Sepsis and bloodstream infections – Caused by susceptible anaerobic bacteria

• Surgical prophylaxis – In procedures with high risk of anaerobic infection

It is suitable for adult patients, and pediatric dosing should be determined by a qualified physician.

Dosage and Administration

• Route: Intravenous infusion only; do not administer as a rapid IV push or bolus.

• Adults: Typically 500 mg every 6–8 hours, depending on infection severity and clinical response.

• Pediatric patients: Dose calculated based on body weight and clinical condition.

• Administer over 30–60 minutes using an appropriate IV infusion set.

• Adjust dose in patients with impaired liver function.

• Duration of therapy varies depending on infection type, severity, and patient response.

Benefits

• Rapid and effective treatment of serious anaerobic bacterial and protozoal infections

• Suitable for patients unable to take oral medications

• Provides systemic bactericidal and protozoacidal activity

• Useful for severe hospital-acquired infections and post-surgical prophylaxis

• Reduces complications and promotes faster recovery in acute infections

Precautions

• Avoid alcohol during treatment and for at least 48 hours after completion to prevent disulfiram-like reactions (nausea, vomiting, flushing).

• Use cautiously in patients with liver impairment or hypersensitivity to metronidazole.

• Pregnancy and breastfeeding: Use only if clearly indicated by a physician.

• Monitor for neurological symptoms in prolonged therapy, including peripheral neuropathy.

• Check for potential drug interactions with anticoagulants and other medications.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects:

• Nausea, vomiting, or diarrhea

• Metallic taste in the mouth

• Mild headache or dizziness

Rare side effects:

• Allergic reactions such as rash or itching

• Peripheral neuropathy with prolonged use

• Severe gastrointestinal disturbances

Storage

• Store below 25°C in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children

• Do not freeze and use only if the solution is clear and free from particles

Varizil Injection 500 mg/100 ml provides effective intravenous therapy for serious anaerobic bacterial and protozoal infections, ensuring rapid action, optimal systemic distribution, and reliable management in hospitalized patients.