Verquv Tablet 5 mg contains Vericiguat, a soluble guanylate cyclase (sGC) stimulator used for the treatment of chronic heart failure with reduced ejection fraction (HFrEF). It is designed for patients who continue to experience symptoms despite receiving standard heart failure therapy. Vericiguat enhances the nitric oxide–sGC–cGMP pathway, promoting vasodilation, improved cardiac function, and reduced cardiac stress, ultimately lowering the risk of hospitalization and cardiovascular death.

This oral tablet formulation allows for convenient once-daily dosing, supporting better adherence and long-term management of heart failure.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Verquv Tablet 5 mg is indicated for:

• Chronic heart failure with reduced ejection fraction (HFrEF)
• Patients with persistent symptoms despite guideline-directed therapy
• Reduction of the risk of heart failure-related hospitalization and cardiovascular mortality

Mechanism of Action

Vericiguat works as a soluble guanylate cyclase stimulator:

• Stimulates sGC, enhancing the nitric oxide (NO) signaling pathway
• Increases cGMP levels, which promotes relaxation of vascular smooth muscles
• Causes vasodilation, reducing both preload and afterload on the heart
• Improves left ventricular function and reduces cardiac remodeling
• Complements other heart failure therapies to slow disease progression

This mechanism improves overall cardiac efficiency and helps control symptoms in chronic heart failure.

Dosage and Administration

• Recommended dose: 5 mg once daily, orally
• Can be taken with or without food
• Swallow the tablet whole with water
• Dose adjustments may be guided by blood pressure, kidney function, and tolerance
• Regular monitoring by a healthcare provider is advised for optimal safety and efficacy

Benefits

• Reduces hospitalization and mortality in patients with HFrEF
• Improves exercise capacity and symptom control
• Convenient once-daily oral dosing enhances adherence
• Works synergistically with other heart failure medications, including ACE inhibitors, beta-blockers, and diuretics
• Supports long-term cardiac function preservation

Side Effects

Common side effects may include:

• Dizziness or lightheadedness
• Low blood pressure (hypotension)
• Headache
• Fatigue

Serious but rare side effects:

• Severe hypotension or syncope
• Allergic reactions (rash, swelling, difficulty breathing)

Seek immediate medical attention if serious or persistent adverse effects occur.

Precautions and Warnings

• Use cautiously in patients with hypotension, severe renal or hepatic impairment
• Avoid concurrent use with nitrates or nitric oxide donors due to risk of severe hypotension
• Monitor blood pressure, kidney function, and electrolytes regularly
• Pregnancy and breastfeeding: only use under medical supervision
• Do not abruptly discontinue therapy without consulting your physician

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Vericiguat may interact with:

• Nitrates or nitric oxide donors (risk of significant hypotension)
• PDE5 inhibitors (enhanced hypotensive effect)
• Medications affecting renal or hepatic clearance

Always inform your healthcare provider of all medications and supplements before starting treatment.

Storage

• Store below 30°C in a dry, cool place
• Protect from light and moisture
• Keep out of reach of children
• Do not use after the expiration date.