Rofuclav Suspension (125 mg + 31.25 mg)/5 ml is a combination antibiotic formulation containing Cefuroxime Axetil and Clavulanic Acid. It is designed to treat a wide range of bacterial infections, particularly in children and patients who prefer liquid medication. This oral suspension provides effective antibacterial action against various susceptible bacteria, helping to control infections and support faster recovery.

Cefuroxime Axetil belongs to the second-generation cephalosporin class of antibiotics, which work by inhibiting bacterial cell wall synthesis. The bacterial cell wall is essential for maintaining the structure and survival of bacteria. By disrupting the formation of the cell wall, Cefuroxime weakens the bacteria, causing them to break down and die.

Clavulanic Acid is a beta-lactamase inhibitor that enhances the effectiveness of Cefuroxime. Some bacteria produce enzymes called beta-lactamases that can destroy certain antibiotics and make them less effective. Clavulanic Acid blocks these enzymes, protecting Cefuroxime from being broken down and allowing it to work more efficiently against resistant bacteria. This combination broadens the antibacterial spectrum and improves treatment success.

Rofuclav Suspension is commonly prescribed for infections affecting the respiratory tract, ear, nose, throat, urinary tract, and skin. It is especially useful in treating infections in pediatric patients due to its liquid formulation and accurate dosing options.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antibiotic

• Second-generation cephalosporin with beta-lactamase inhibitor

Composition

Each 5 ml of reconstituted suspension contains:

• Cefuroxime Axetil – 125 mg

• Clavulanic Acid – 31.25 mg

This combination provides enhanced protection against bacteria that may otherwise resist standard antibiotic therapy.

Indications

Rofuclav Suspension (125 mg + 31.25 mg)/5 ml is indicated for the treatment of several bacterial infections, including:

• Respiratory tract infections such as bronchitis and pneumonia

• Ear infections (otitis media)

• Sinus infections (sinusitis)

• Throat infections including tonsillitis and pharyngitis

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

A healthcare professional will determine the appropriate use based on the patient’s symptoms and medical condition.

Mechanism of Action

The combination works through a dual mechanism:

• Cefuroxime Axetil stops bacteria from forming protective cell walls, leading to bacterial death.

• Clavulanic Acid blocks beta-lactamase enzymes produced by resistant bacteria, allowing Cefuroxime to remain active and effective.

This synergistic action improves the antibiotic’s ability to treat resistant bacterial infections.

Dosage and Administration

• The dosage is usually determined by the doctor based on the patient’s age, weight, and severity of infection.

• The suspension should be shaken well before each use to ensure uniform distribution of the medicine.

• It is generally recommended to take the medication after meals to improve absorption and reduce stomach discomfort.

• The complete course of treatment should be finished as prescribed.

Caregivers should follow the dosing instructions carefully to ensure effective treatment.

Possible Side Effects

Common side effects may include:

• Nausea or vomiting

• Diarrhea

• Mild abdominal discomfort

• Skin rash

• Headache

Most side effects are mild and temporary. However, severe allergic reactions should be reported to a healthcare provider immediately.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Inform the doctor if the patient has allergies to cephalosporins, penicillins, or other antibiotics.

• Use with caution in individuals with kidney or liver disorders.

• Do not use without a confirmed or suspected bacterial infection.

• Always complete the prescribed antibiotic course to avoid resistance.

Storage

Store the dry powder below 30°C in a cool and dry place. After reconstitution, keep the suspension tightly closed and use it within the recommended period mentioned on the label.