Vorifast Injection 200 mg/vial contains Voriconazole, a broad-spectrum triazole antifungal medicine used for the treatment of serious and life-threatening fungal infections. It is commonly used in hospital settings for invasive aspergillosis, severe candidiasis, and other systemic fungal infections, particularly in immunocompromised patients such as those undergoing chemotherapy, organ transplantation, or suffering from severe immune suppression.

Voriconazole works by inhibiting fungal cytochrome P450-dependent enzyme lanosterol 14-α-demethylase. This enzyme is essential for the synthesis of ergosterol, a key structural component of fungal cell membranes. By blocking ergosterol formation, Voriconazole disrupts fungal cell membrane integrity, leading to inhibition of fungal growth and eventual cell death.

Vorifast Injection provides rapid and reliable antifungal action and is often used when oral therapy is not suitable or when immediate systemic treatment is required. It may be used as initial therapy (loading dose) followed by oral maintenance therapy, depending on the patient’s condition and clinical response.

This medicine should only be administered under strict medical supervision in a hospital or clinical setting. Careful monitoring of liver function, kidney function, and overall clinical status is necessary during treatment to ensure safety and effectiveness.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Voriconazole USP 200 mg

Indications

Vorifast Injection is indicated for:

• Invasive aspergillosis
• Serious Candida infections
• Esophageal candidiasis (when oral therapy is not suitable)
• Scedosporium infections
• Fusarium infections
• Severe systemic fungal infections in immunocompromised patients

How It Works

Voriconazole inhibits the fungal enzyme lanosterol 14-α-demethylase, preventing ergosterol synthesis. This weakens the fungal cell membrane, disrupts cell function, and leads to fungal cell death.

Dosage and Administration

Vorifast Injection must be administered by a qualified healthcare professional.

• Given by intravenous infusion only
• Dosage depends on body weight, infection severity, and patient response
• Often started with a loading dose followed by maintenance dosing as prescribed
• Infusion should be given slowly to reduce risk of adverse reactions

Regular monitoring of liver enzymes and clinical response is required throughout therapy.

Benefits of Vorifast Injection

• Provides rapid antifungal action in severe infections
• Effective against a broad range of systemic fungal pathogens
• Suitable for critically ill or hospitalized patients
• Useful when oral therapy is not possible
• Part of standard treatment for invasive fungal infections

Precautions

Use cautiously in:

• Patients with liver impairment
• Patients with cardiac arrhythmias or QT prolongation
• Renal impairment (monitor closely during IV use)
• Pregnant or breastfeeding women unless clearly necessary

Patients should be closely monitored for visual changes, liver toxicity, and drug interactions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Fever
• Nausea and vomiting
• Headache
• Visual disturbances (blurred or altered vision)
• Elevated liver enzymes
• Rash
• Abdominal discomfort

Serious reactions such as liver failure, severe allergic reactions, or cardiac rhythm disturbances require immediate medical attention.

Storage

• Store below 30°C
• Protect from light
• Keep in original packaging until use
• Keep out of reach of children.