Xelmet XR Tablet 500 mg contains Metformin Hydrochloride in an extended-release (XR) formulation, designed to provide a gradual and sustained release of the medicine throughout the day. It is used in the management of type 2 diabetes mellitus and helps maintain stable blood glucose control with improved gastrointestinal tolerability compared to immediate-release formulations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Xelmet XR Tablet 500 mg is indicated for:

• Management of type 2 diabetes mellitus in adults
• Initial or maintenance therapy in diabetic patients requiring oral antidiabetic treatment
• Combination therapy with other antidiabetic agents or insulin
• Insulin resistance conditions such as polycystic ovary syndrome (PCOS), as prescribed

Mechanism of Action

Metformin XR works through the same active mechanism as standard Metformin, with prolonged action:

• Reduces hepatic glucose production (gluconeogenesis)
• Enhances peripheral glucose uptake and insulin sensitivity
• Improves utilization of glucose in muscle tissues
• Decreases intestinal absorption of glucose

The extended-release formulation allows slower absorption, resulting in steadier blood levels and reduced gastrointestinal side effects.

Dosage and Administration

• Dosage should be individualized based on blood glucose control and physician recommendation
• Typically taken once daily with the evening meal
• Swallow the tablet whole; do not crush, chew, or split
• Regular monitoring of blood glucose levels is recommended
• Dose adjustments may be required based on therapeutic response

Benefits

• Provides 24-hour blood glucose control with once-daily dosing
• Improves patient compliance due to reduced dosing frequency
• Lower incidence of gastrointestinal side effects compared to immediate-release Metformin
• Helps control fasting and post-meal blood sugar levels
• Low risk of hypoglycemia when used alone

Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Abdominal discomfort
• Flatulence
• Mild loss of appetite

Rare but serious side effect:

• Lactic acidosis, particularly in patients with kidney or liver impairment

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use cautiously in patients with renal or hepatic dysfunction
• Avoid excessive alcohol consumption
• Temporary discontinuation may be required before radiological procedures using contrast media
• Not recommended in severe kidney disease
• Kidney function should be monitored regularly during therapy

Storage

• Store below 25°C
• Protect from moisture and heat
• Keep out of reach of children.