Yonex Injection 4.5 MIU (150 mg) contains Colistimethate Sodium, an antibiotic belonging to the polymyxin group. It is used for the treatment of serious infections caused by multidrug-resistant Gram-negative bacteria, especially when other antibiotics are not effective or suitable. It is commonly used in hospital settings for life-threatening infections.

Colistimethate Sodium is a prodrug that is converted in the body into colistin, the active antibacterial agent. It works by damaging the bacterial cell membrane, leading to leakage of cellular contents and rapid bacterial cell death. Due to its potency, it is reserved for severe infections caused by resistant organisms such as Pseudomonas aeruginosa, Klebsiella species, and Acinetobacter species.

Yonex Injection is administered only under strict medical supervision, usually in intensive care or hospital environments. Dosage is carefully adjusted based on kidney function, infection severity, and patient response. Regular monitoring is essential to ensure safety and effectiveness.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Colistimethate Sodium USP 4.5 MIU (equivalent to 150 mg)

Indications

Yonex Injection is indicated for:

• Severe infections caused by multidrug-resistant Gram-negative bacteria
• Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP)
• Bloodstream infections (sepsis)
• Urinary tract infections caused by resistant organisms
• Intra-abdominal infections
• Other serious systemic infections when alternative antibiotics are ineffective

How It Works

Colistimethate Sodium is converted into colistin in the body. Colistin binds to lipopolysaccharides and phospholipids in the bacterial cell membrane, disrupting membrane integrity. This causes leakage of intracellular components and leads to bacterial cell death.

Dosage and Administration

Yonex Injection should be administered by a qualified healthcare professional.

• Given by intravenous infusion or intramuscular injection
• Dose depends on body weight, severity of infection, and kidney function
• Requires careful adjustment in renal impairment
• Regular monitoring of kidney function is essential during therapy

Benefits of Yonex Injection

• Effective against multidrug-resistant Gram-negative bacteria
• Useful in life-threatening hospital-acquired infections
• Important option when other antibiotics fail
• Rapid bactericidal action
• Critical drug in intensive care settings

Precautions

Use cautiously in:

• Kidney impairment (high risk of nephrotoxicity)
• Neuromuscular disorders
• Elderly patients
• Patients receiving other nephrotoxic drugs
• Pregnancy and breastfeeding only if clearly necessary

Renal function and neurological status should be closely monitored during treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Kidney toxicity (elevated creatinine)
• Nausea and vomiting
• Dizziness
• Tingling or numbness
• Neuromuscular weakness
• Injection site reactions

Serious adverse effects require immediate medical attention.

Storage

• Store below 25–30°C (as per product guidelines)
• Protect from light and moisture
• Keep out of reach of children.