Zentixol D Injection 200 mg/ml is a long-acting depot antipsychotic containing Zuclopenthixol. It is designed for the treatment of chronic psychotic disorders such as schizophrenia, particularly in patients who have poor compliance with oral medications. This formulation provides sustained therapeutic levels of medication, reducing the need for daily dosing and improving adherence to long-term treatment plans.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Typical Antipsychotic – Thioxanthene Derivative

Indications

Zentixol D Injection is indicated for:

• Schizophrenia and other chronic psychotic disorders

• Patients with schizophrenia who are non-compliant or intolerant to oral antipsychotic therapy

• Agitated or violent psychotic patients requiring rapid and sustained symptom control

By providing steady plasma levels, Zentixol D helps in preventing relapse and maintaining symptom control over extended periods.

Pharmacology

Zuclopenthixol is a thioxanthene derivative and a typical antipsychotic. Its primary therapeutic effect is achieved through antagonism of dopamine D1 and D2 receptors in the brain. Blockade of these receptors reduces psychotic symptoms such as hallucinations, delusions, and agitation. Zentixol D also exhibits antagonistic activity at α1-adrenergic, histamine H1, and muscarinic cholinergic receptors, which contributes to its sedative and anti-agitation effects.

The depot formulation ensures slow release of Zuclopenthixol into the bloodstream, allowing for prolonged action and minimizing peak-related side effects.

Dosage and Administration

• Zentixol D Injection is administered intramuscularly by a trained healthcare professional.

• The usual starting dose for adults: 200 mg every 2–4 weeks, depending on clinical response and prior antipsychotic treatment.

• Dosage should be individualized based on patient response, severity of symptoms, and previous antipsychotic exposure.

• For maintenance therapy, injection intervals may be extended to 4 weeks if stable.

• Not recommended for pediatric use; caution advised in elderly patients.

Important: Always rotate injection sites to minimize local irritation and monitor for injection site reactions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Concomitant use with other CNS depressants or alcohol may enhance sedation.

• May interact with antihypertensive agents, increasing the risk of orthostatic hypotension.

• Use with caution in combination with drugs that prolong the QT interval or lower seizure threshold.

Contraindications

• Known hypersensitivity to Zuclopenthixol or other thioxanthene derivatives

• Severe CNS depression, comatose states, or uncontrolled epilepsy

• Myocardial infarction, severe cardiovascular disorders, or arrhythmias

• Pregnancy and breastfeeding unless clearly necessary

Side Effects

Common:

• Sedation, drowsiness

• Extrapyramidal symptoms (tremor, rigidity, akathisia)

• Hypotension and dizziness

• Dry mouth, constipation, blurred vision

Serious but rare:

• Neuroleptic malignant syndrome (NMS)

• Severe extrapyramidal reactions or tardive dyskinesia

• Agranulocytosis and other hematological effects

• Prolonged QT interval and cardiac arrhythmias

Precautions and Warnings

• Monitor patients for signs of extrapyramidal symptoms, tardive dyskinesia, and NMS

• Regular cardiovascular monitoring is recommended, especially in patients with pre-existing heart disease

• Caution in patients with seizure disorders, diabetes, or hepatic/renal impairment

• Avoid abrupt discontinuation; dose adjustments should be gradual

Pregnancy and Lactation

• Use in pregnancy only if benefits outweigh risks; safety in lactation is not established

• Alternative therapies should be considered for nursing mothers

Storage Conditions

Store below 30°C in a dry place, protected from light. Keep out of reach of children. Avoid freezing the injection.